Efficacy of injectable platelet-rich fibrin associated with particulated deproteinized bovine bone mineral in horizontal maxillary regeneration – a randomized, triple blinded, split-mouth controlled clinical trial
In edentulous maxilla with insufficient bone width, both the association of i-PRF+DBBM and DBBM alone were effective in providing bone width gain for implant placement, and the association of DBBM with i-PRF showed similar outcomes compared with DBBM alone for the studied parameters.
Using RST for socket sealing achieves comparable bone preservation to the GBR in severe defect molars, while simplifying the surgical procedure and reducing costs.
Maton's Trichrome staining may improve discrimination between osteoid/collagen matrix and mineralized tissue interfaces during histomorphometric analysis during histomorphometric analysis.
K. Gabel, B. Mealey, Michael P. Mills et al.· The Journal of Periodontolog...· 0 citations
T-PRF was associated with improved radiographic healing of extraction sockets, as reflected by a lower residual non-ossified socket volume after 3 months compared with spontaneous healing, which may represent a simple, autologous, and clinically useful adjunct for socket preservation prior to implant placement.
Yunus İbiloğlu, İzzet Melih Gürkan, H. Özdemir· European Journal of Therapeu...· 0 citations
Adequate peri-implant soft tissue thickness and keratinized mucosa width are crucial for implant health and aesthetics. Autogenous subepithelial connective tissue grafts (CTG) are the gold-standard for augmenting thin biotypes, but they require a second surgical site. This trial evaluated whether a human fascia lata allograft (FLA) or platelet-rich fibrin (PRF) membrane could comparably enhance peri-implant soft tissue phenotype and serve as less invasive alternatives of CTG. Forty-five patients with a thin gingival phenotype (≤ 1 mm thickness) requiring upper anterior implant were randomly assigned to receive soft tissue augmentation with either (1) FLA allograft, (2) PRF membrane, or (3) CTG (control). Interventions were applied concurrently with implant placement in a standardized manner. Gingival thickness (GT) and keratinized tissue width (KTW) were measured at baseline and 6 months using transgingival probing and clinical indices. Labial bone thickness was assessed by cone-beam CT at implant placement and 6 months. Forty-five enrolled patients completed the study. All treatment modalities showed improvements in gingival and bone parameters, with the connective tissue graft consistently demonstrating the greatest gains. The median keratinized tissue width increased to 4.00 mm in the Connective Tissue Graft group, slightly higher than the Fascial Lata Allograft and Platelet-Rich Fibrin groups (3.75 mm). Gingival thickness showed significant increases in all groups, with the Connective Tissue Graft reaching 2.15 mm, followed by Fascia Lata Allograft (1.80 mm) and Platelet-Rich Fibrin (1.55 mm). Labial bone thickness also increased, with the Connective Tissue Graft achieving the highest mean value of 2.300 mm, and after 6 months, significant gains were observed in both this group (p = 0.032) and in the Platelet-Rich Fibrin group (p = 0.044), while Fascia Lata Allograft showed a smaller, non-significant increase. Both fascia lata allograft (FLA) and PRF improved peri-implant soft tissue parameters, however the connective tissue graft (CTG) remains the gold standard for achieving the greatest thickness and best aesthetic results. FLA is a promising alternative that avoids a second surgical site with comparable outcomes, whereas PRF offers faster healing but lacks the volume necessary for significant tissue modification.
Ahmed Mohamed Elhadidy, H. H. Hazzaa, A. Elgendy et al.· BMC Oral Health· 0 citations
Background: Prolonged orthodontic treatment duration remains a major clinical concern because of its association with root resorption, enamel decalcification, periodontal complications, and reduced patient compliance. Injectable platelet-rich fibrin (I-PRF), a second-generation autologous platelet concentrate rich in growth factors and inflammatory mediators, has recently gained attention as a minimally invasive adjunct for accelerating orthodontic tooth movement (OTM). Aim was to evaluate the effectiveness of I-PRF on the rate of OTM during maxillary canine retraction.
Methods: This prospective split-mouth clinico-experimental study included nine patients requiring bilateral maxillary first premolar extractions for orthodontic treatment. The right maxillary quadrant received intraligamentary I-PRF injections, while the contralateral side served as the control. Canine retraction was performed using nickel-titanium closed-coil springs delivering 150 g force on 0.019″×0.025″ stainless steel archwires. I-PRF was prepared using low-speed centrifugation at 700 rpm for 3 minutes and administered at baseline and eighth week. OTM was evaluated monthly for three months using three-dimensional digital model superimposition. Statistical analysis included paired t-test, repeated measures ANOVA, and Bonferroni post-hoc analysis.
Results: The I-PRF group demonstrated greater OTM compared to the control group at all evaluated intervals. Statistically significant differences were observed during the initial phase of retraction and in cumulative tooth movement from baseline to the third month. Repeated measures ANOVA revealed significant variation in tooth movement across different intervals in both groups.
Conclusions: I-PRF demonstrated a positive effect on accelerating OTM and may serve as an effective, minimally invasive biologic adjunct for enhancing orthodontic treatment efficiency.
Benezer Rapsang, Vaibhav Misra, A. Garg et al.· International Journal of Cli...· 0 citations
BACKGROUND
This prospective study aimed to assess the clinical outcomes and patient-related outcome measures (PROMs) of open flap debridement (OFD) alone versus open flap debridement with leukocyte-platelet-rich fibrin (L-PRF).
METHODS
Twenty-one patients were enrolled into a split-mouth randomized clinical trial. One side of the arch underwent OFD; the contralateral side of the same arch underwent the same OFD procedure with L-PRF placed across the alveolar bone and root surfaces underneath the buccal and lingual/palatal flap. Clinical parameters for probing depth (PD) and relative gingival recession (RGR) were recorded at six sites per tooth using a thermoplastic stent at baseline (immediately before surgery), 3 months, and 6 months. Bleeding on probing (BOP) and plaque scores were recorded at six sites per tooth throughout the study duration.
RESULTS
The greatest reductions in PD were observed for sites ≥ 7 mm. Mean PD in the control group decreased from 7.38 mm at baseline to 3.15 mm at 3 months, with a subsequent increase to 4.00 mm at 6 months. In contrast, the test group demonstrated a sustained reduction from 7.75 mm at baseline to 3.25 mm at 3 months and 3.19 mm at 6 months. In moderate sites (4-6 mm), both groups demonstrated substantial PD reduction. Moderate subgroup mean PD decreased from 4.62 mm to 3.09 mm in the control group and from 4.76 mm to 3.19 mm in the test group at the 6-month timepoint. Relative recession and relative attachment level revealed no significant differences between the groups across all PDs. PROMs data showed that, although test group patients reported more swelling and pain early after surgery, they used less analgesics than the control group.
CONCLUSIONS
Based on the findings from this randomized clinical study, L-PRF was found to have improved, sustained PD reduction in deep periodontal pockets compared to OFD alone. L-PRF was not found to have a significant impact on PROMs or soft tissue healing compared to OFD alone.
CLINICALTRIALS
GOV IDENTIFIER
NCT06296498 PLAIN LANGUAGE SUMMARY: In this split mouth, same arch clinical study, 21 patients were randomized into two study groups: open flap debridement (OFD) and OFD plus leukocyte-platelet-rich fibrin (L-PRF). Clinical parameters were recorded at baseline, 3 months, and 6 months after intervention, while healing and patient-reported outcome measures (PROMs) were evaluated 2 and 4 weeks after surgery. In sites ≥ 7 mm baseline PD, OFD plus L-PRF was associated with greater probing depth (PD) reduction and attachment level (AL) gain than control OFD alone, with similar gingival recession in both groups. Overall test group PD decrease was 4.44 mm, resulting in 1.05 mm more PD decrease in test sites than control. L-PRF effect was sustained with PD values in test sites reduced to 3.25 mm and 3.19 mm at 3 and 6 months, respectively (from 7.75 mm at baseline). The addition of L-PRF did not provide benefits in PROMs and soft tissue healing compared to sites treated with OFD alone.
J. Sides, A. Palaiologou, B. Mealey et al.· The Journal of Periodontolog...· 0 citations