Aug 2026· The European Research Journal· 0 citations· 9 references
TL;DR
Female patients predominated slightly, and the incidence of gastric and esophageal cancers was significantly higher than reported in the literature, suggesting that regional environmental, dietary, and sociocultural factors play a critical role in shaping cancer distribution across the Eastern Anatolia region.
Abstract
Objective: Cancer epidemiology may exhibit regional variations depending on geographical, environmental, and sociocultural factors. The aim of this study was to evaluate the sex distribution and cancer diagnoses of patients admitted to the Van province region and to compare the findings with current national and international literature.
Methods: This study was designed as a single-center, retrospective, and descriptive study. A total of 728 patients who were admitted to the Medical Oncology Outpatient Clinic of Van Training and Research Hospital between January 1, 2024, and December 31, 2024, and whose malignancy diagnoses were histopathologically confirmed were included. Patient sex and cancer diagnoses were obtained from hospital records. Data were analyzed using descriptive statistics, and categorical variables were presented as numbers (n) and percentages (%).
Results: Of the 728 patients included in the study, 387 (53.2%) were female and 341 (46.8%) were male. The most common cancer diagnoses were breast cancer (21.2%), gastric cancer (19.4%), esophageal cancer (10.7%), lung cancer (8.5%), and colorectal cancer (6.5%). Upper gastrointestinal system cancers, specifically gastric and esophageal malignancies, combined to constitute nearly one-third (30.1%) of the total patient population. Sex-specific analysis revealed a strong female predominance in breast cancer (97.4%), male predominance in gastric and lung cancers, and a nearly equal sex distribution in esophageal cancer.
Conclusions: Female patients predominated slightly, and the incidence of gastric and esophageal cancers was significantly higher than reported in the literature. These findings suggest that regional environmental, dietary, and sociocultural factors play a critical role in shaping cancer distribution across the Eastern Anatolia region.
Lung cancer patients attending Nobel Medical College Teaching Hospital predominantly presented at advanced stages, and adenocarcinoma was the leading histological subtype.
Pradip Bhandari· Journal of Nobel Medical Col...· 0 citations
Objective: The objective of this study is to describe the prevalence and distribution of demographic and reproductive characteristics among patients diagnosed with endometriosis at a tertiary referral hospital in Palembang, Indonesia.Methods: This is a descriptive cross-sectional study that was conducted on secondary medical record data of women with histopathologically-confirmed endometriosis between the period of July 2022 to December 2024 to achieve the objective mentioned previously by applying total sampling. Variables analyzed included age, age at menarche, menstrual cycle pattern, disease stage based on the revised American Society for Reproductive Medicine classification, marital status, parity, and body mass index. Data were then summarized using descriptive statistics.Results: A total of 507 patients were included. The highest number of cases occurred in 2024 (57.2%). Most patients were aged between 15 – 49 years (98.4%), had menarche at 8 – 15 years (98.8%), and regular menstrual cycles (98.0%). Stage IV was predominant (61.1%). Nearly half were nulliparous (49.5%), were married (94.1%), and had normal body mass index (38.5%).Conclusion: Most patients with endometriosis in this study were of reproductive age and were predominantly diagnosed at an advanced stage with nulliparity frequently observed.Distribusi dan Karakteristik Klinis Endometriosis di Rumah Sakit Rujukan Tersier di Indonesia: Studi Potong LintangAbstrakTujuan: Penelitian ini bertujuan untuk mendeskripsikan prevalensi dan distribusi karakteristik demografi serta reproduksi pasien endometriosis di rumah sakit rujukan tersier di Palembang, Indonesia.Metode: Metode yang digunakan dalam penelitian ini adalah metode deskriptif dengan desain potong lintang menggunakan data sekunder rekam medis pasien endometriosis yang terkonfirmasi secara histopatologi periode Juli 2022 hingga Desember 2024. Variabel yang dianalisis meliputi usia, usia menarche, pola siklus menstruasi, derajat berdasarkan klasifikasi Revised American Society for Reproductive Medicine, status pernikahan, paritas, dan indeks massa tubuh. Data dianalisis menggunakan statistik deskriptif.Hasil: Hasil penelitian menunjukkan bahwa sebanyak 507 pasien memenuhi kriteria. Kasus terbanyak ditemukan pada tahun 2024 (57,2%). Mayoritas pasien berusia 15 – 49 tahun (98,4%), usia menarche 8 – 15 tahun (98,8%), dan siklus menstruasi teratur (98,0%). Stadium IV mendominasi (61,1%). Sebanyak 49,5% pasien merupakan nulipara, 94,1% telah menikah, dan 38,5% memiliki indeks massa tubuh normal.Kesimpulan: Sebagian besar pasien endometriosis dalam penelitian ini merupakan wanita usia reproduktif dan terdiagnosis pada stadium lanjut dengan nuliparitas sebagai karakteristik yang sering ditemukan.
Salsabila Aisyah Putri, Yusuf Effendi, A. Martadiansyah et al.· Indonesian Journal of Obstet...· 0 citations
Purpose: Differentiated thyroid carcinoma (DTC) is the most common endocrine malignancy, with its incidence rising worldwide. This study aimed to evaluate the demographic and clinical characteristics of patients with DTC treated at Pamukkale University and to compare them with national and international data. In addition, the study was designed as an educational initiative, offering medical students practical experience in research methodology.Materials and methods: A total of 299 patients (246 females, 53 males) who underwent thyroidectomy and were referred for radioiodine ablation between January 2014 and December 2021 were retrospectively analyzed. Age, sex, histological subtype, tumor size, focality, lymph node involvement, distant metastasis, and administered radioiodine activity (RAI) were collected. Statistical analyses were performed using SPSS version 25.0.Results: The mean age at diagnosis was 47.3±14.2 years (46.9 for females, 48.9 for males), with a female-to-male ratio of 4.8:1. The classical variant of papillary thyroid carcinoma was the most frequent subtype (74.4%), followed by the follicular variant (12%) and oncocytic thyroid carcinoma (OTC) (7.4%). Regional lymph node metastases were observed in 16.4% and distant metastases in 3.0% of patients. Follicular thyroid carcinoma (FTC) was associated with a higher rate of distant metastasis compared with papillary thyroid carcinoma (PTC) (10.5% vs. 3%). Regarding treatment, 72% of patients received ≤100 mCi radioiodine, while 20% received >100 mCi.Conclusion: Female sex and papillary histopathology are predominant in DTC. Follicular thyroid carcinoma tends to exhibit a higher propensity for distant metastasis compared with papillary thyroid carcinoma. The dual purpose of this study highlights both its epidemiological contribution and its role in training medical students in applied research methodology.
A. Gültekin, Enes Akbaş, Furkan Ay et al.· Pamukkale Medical Journal· 0 citations
SUMMARY OBJECTIVE: The aim of this study was to describe the clinical-epidemiological profile and outcome in patients under 15 years of age with differentiated thyroid cancer diagnosed at a state pediatric referral service in Santa Catarina, Brazil, from 2011 to 2020. METHODS: Retrospective cohort study analyzing the medical records of 16 patients with differentiated thyroid cancer. The variables analyzed were gender, age, year of diagnosis, previous exposure to radiation, personal and family medical history, symptoms/signs at diagnosis, histological type, staging, therapy, surgical complications, remission rate, and vital status. RESULTS: Differentiated thyroid cancer occurred in females and adolescents in 62.5% of cases, respectively. Previous radiotherapy was reported in 25% of cases. On physical examination, 56% had a thyroid nodule. Papillary carcinoma was diagnosed in 81.25% of cases. Four patients (25%) were classified as high risk and three never achieving remission. All five low-risk patients and four of the five intermediate-risk patients were in remission. Total thyroidectomy, with or without lymph node resection, was indicated in all cases. Transient hypoparathyroidism occurred in 25%. Radioiodine therapy with I-131 was used in 68.75% of cases, including two low-risk patients treated before 2015. The remission rate was 75%. There were no deaths. CONCLUSION: Papillary carcinoma is the most common histological type, predominantly in adolescents and females. Previous radiotherapy is a risk factor for differentiated thyroid cancer. The most frequent presentation is a thyroid nodule. Total thyroidectomy is the standard procedure. Radioiodine therapy is not indicated for low-risk patients after 2015. Transient hypoparathyroidism is the most common surgical complication. The remission rate for differentiated thyroid cancer is high.
Denise Bousfield da Silva, Larissa Cubas, Jefferson Traebert et al.· Revista da Associação Médica...· 0 citations
Patients with prostate cancer presented at a late stage, with locally advanced and metastatic disease, most patients had moderately or poorly differentiated adenocarcinoma and androgen deprivation therapy was the treatment modality for most patients.
O. E. Akaiso, A. Ukpong, Elijah A. Udoh· Journal of Advances in Medic...· 0 citations
Background Multiple primary malignancies (MPM) are the subsequent malignancies occurring in an individual with an already diagnosed malignancy. This study was conducted to determine the proportion, clinicopathological characteristics, treatment intent and overall survival of MPMs detected in patients at a tertiary care cancer centre in North Kerala, India.
Materials & Methods The case records of 11250 patients who presented to our institution between January 2021 and December 2022 were retrospectively evaluated for the presence of MPMs. The MPMs were defined by the IARC/IACR criteria. The patient details were recorded from archives. Descriptive statistics were used for categorical variables. The patients were followed up for a minimum period of 2 years and overall survival was calculated.
Results Out of the 11250 patients who presented to our institution between January 2021 and December 2022, 121 patients had MPMs (1.08%). 115 (95%) patients were found to have double primary malignancies. Triple primary malignancies were identified in 6 (5%) patients. 38 patients were found to have SyPMs (33%) and 77 with McPMs (67%). Breast was the most common index primary malignancy (41; 35.6%) followed by colon (15; 13%) and gynecologic malignancies (14; 12.2%). The patients with McPM had better overall survival than SyPMs.
Conclusion The increasing proportion of multiple primary malignancies should raise the suspicion of second primaries while evaluating and following up patients with malignancies. Efforts must be made to diagnose the second primaries in the earlier stage so that a curative treatment can be offered.
Saranya Purushothaman, S. Nayanar, P. Shenoy et al.· Annals of Pathology and Labo...· 0 citations