The Rosa roxburghii genome provides insights into triterpenoid metabolism.

Genome analysis of the glycosphingolipid-producing green alga Tetraselmis sp. NKG400013.

A genomic framework for understanding the high glycosphingolipid-producing capacity of NKG400013 is established and insights into the evolutionary diversification of sphingolipid metabolism in green algae are provided.

Transcriptomic landscape of Cestrum diurnum: elucidating pathways of medicinally important terpenoids and toxic alkaloids

Genomic exploration of Serratia rubidaea MJ24 uncovers diverse biosynthetic capacity and agricultural relevance

The findings reveal S. rubidaea MJ24 as a metabolically versatile bacterium with a rich secondary metabolite repertoire and significant agricultural and biotechnological promise.

The genome, transcriptome and metabolome of Aspergillus welwitschiae Ocstreb1 from wild halophytic rice, Oryza coarctata, indicates its distinctiveness.

An integrated omics study provides foundational insights into the endophytic potential and genomic distinctiveness of AwOcstreb1, isolated from halophytic rice, and opens new avenues for exploring A. welwitschiae for sustainable agriculture and fungal biology.

Divergent Lineage of Terpene Synthases Establishes Terpenoid Biosynthesis in Brown Macroalgae.

Brown algal terpene synthases separate into two subgroups, with mono- and diTSs containing putative chloroplast-targeting sequences while sesquiTSs lack them, suggesting convergent compartmentalization of terpene biosynthesis with land plants.

Snapshot at Saccharomycopsis fibuligera metabolism for industrial terpenoid production and bioengineering.

BACKGROUND Microbial metabolic engineering increasingly depends on identifying robust non-conventional yeast chassis with favorable metabolic traits. Although Saccharomyces cerevisiae remains the main model for isoprenoid engineering, alternative yeasts may provide superior native precursor availability. Here, we report the first comparative metabolomic characterization of Saccharomycopsis fibuligera, focusing on the mevalonate and terpenoid backbone biosynthesis pathways. RESULTS LC-MS profiling revealed elevated levels of acetyl-CoA, HMG-CoA, and MVA in S. fibuligera, suggesting strong native flux through the MVA pathway. The universal isoprenoid precursors IPP and DMAPP accumulated at substantially higher levels than in S. cerevisiae, together with enrichment of FPP and ergosterol abundance, indicating efficient channeling toward sterol biosynthesis. Conversely, upper glycolysis metabolites were reduced, while TCA cycle intermediates were enriched, supporting the proposed Crabtree-negative phenotype of S. fibuligera. Amino acid profiling also indicated enhanced nitrogen storage capacity. CONCLUSIONS These results position S. fibuligera as a metabolically favorable platform with high intrinsic MVA pathway activity and precursor availability for terpenoid production, highlighting its strong potential as an emerging microbial chassis for next‑generation terpenoid bioproduction.