Sep 2026· Current Treatment Options in Oncology· Vol 27· 0 citations· 61 references
Medicine
TL;DR
Overall, TIL therapy constitutes a rapidly evolving and clinically potent treatment modality for melanoma and covers recent advances for improving therapeutic outcomes, including safety optimization, product optimization, next-generation engineered TILs, and predictive biomarkers.
Emerging clinical evidence and mechanistic insights into OV–ICI synergy are synthesized to inform rational trial design, refine combination strategies, and accelerate the development of precision immuno-oncology approaches.
Esophageal carcinoma (EC) remains one of the most lethal malignancies, with a five-year survival rate of only 15-25% in advanced stages. Although immunotherapy including immune checkpoint inhibitors (ICIs) and antibody-based therapies have improved clinical outcomes, durable responses are confined to a minority of pati...
Zheng-Lin He, Han-Ming Hao, Xin-Yang Shu et al.· Frontiers in Immunology· 0 citations
Cutaneous melanoma remains a global health challenge. Although BRAF/MEK-targeted therapies and immune checkpoint inhibitors (ICIs) have improved outcomes in advanced disease, durable responses remain difficult to achieve for most patients. Therapeutic resistance represents the central barrier to long-term disease contr...
Nicolas Moussallem, Ali Awada, Roy El Darzi et al.· Pharmaceuticals· 0 citations
This review aims to discuss current and emerging treatment approaches based on modulation of the immune response, with particular emphasis on immune checkpoint inhibitors, targeted therapies, and mRNA vaccines.
Artur Marcysiak, Patrycja Mularczyk, Nina Polek et al.· 1 citation
The immunological characteristics of TNBC, the current status of ICI-based therapy, and the underlying mechanisms of resistance are reviewed, which summarizes the biological rationale for combining RT with ICIs in the treatment of TNBC and explores the impact of different RT dose-fractionation regimens, treatment seque...
Lu Wang, Xin Bai, Fan Wang et al.· Frontiers in Immunology· 0 citations
Current and emerging treatment approaches based on modulation of the immune response, with particular emphasis on immune checkpoint inhibitors, targeted therapies, and mRNA vaccines are discussed.
Artur Marcysiak, Patrycja Mularczyk, Nina Polek et al.· International Journal of Inn...· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
