Jul 2026· ACS Applied Bio Materials· 0 citations· 42 references
Medicine
TL;DR
A multifunctional CeO2/PCL nanofibrous scaffold integrating real-time pH sensing, enhanced stem cell adhesion, and antioxidant functions was developed and exhibited significant antibacterial activity, potent reactive oxygen species scavenging capability, and excellent biocompatibility.
Abstract
The delayed healing of skin wounds poses significant health risks and increases medical burdens, necessitating the development of multifunctional dressings that can actively monitor and promote the healing process. In this study, a multifunctional CeO2/PCL nanofibrous scaffold integrating real-time pH sensing, enhanced stem cell adhesion, and antioxidant functions was developed. A series of composite scaffolds with tunable CeO2 nanoparticle loadings (7.1-31.6 wt %) were fabricated via a facile one-step electrospinning technique. Notably, the CeO2/PCL-13.3 wt % scaffold achieved an optimal balance of tensile strength (1.927 MPa) and elongation at break (70%), fully satisfying clinical wound dressing requirements. Phenol red loading enabled naked-eye pH monitoring (4.0-10.0) via metal-phenolic coordination. Comprehensive evaluations demonstrated that the composite scaffolds exhibited significant antibacterial activity, potent reactive oxygen species scavenging capability, and excellent biocompatibility. The scaffolds maintained over 80% human umbilical cord mesenchymal stem cells viability within 72 h and significantly promoted stem cell migration in wound healing assays. This integrated platform unifies visual diagnostics and therapeutic functions for advanced wound management.
A multifunctional hydrogel patch developed by chemically modifying chitosan with N-acetylsulfonyl chloride and forming a cross-linked network with polyvinylpyrrolidone (PVP) represents a promising multifunctional dressing for the effective management of infected wounds.
Insha Kakroo, Nayeema Gull, Insha Mehraj et al.· ACS Applied Bio Materials· 0 citations
Findings suggest that the synthesized hydrogel (BSG‐CHI) provides a favorable microenvironment for tissue regeneration and wound management applications.
Durgesh Kumar, Suhela Tyeb, Baby Shruit Shukla et al.· MedComm – Biomaterials and A...· 0 citations
Developing multifunctional scaffolds that combine tailored physical properties with bioactivity is essential for advanced bone tissue engineering. This study fabricated an interleukin-4 (IL-4)-loaded polycaprolactone/gelatin (PCL-Gel) nanofiber membrane via electrospinning. Incorporating Gel significantly refined fiber diameter (978 ± 324 nm, 883 ± 234 nm for PCL), increased surface roughness, and improved hydrophilicity, reducing the water contact angle from 161.3° to 43.3°. IL-4 was successfully encapsulated without altering fiber morphology. The composite membrane exhibited a sustained release profile with a low initial burst (20%–30%) and high cumulative release (>85% over 30 d). In vitro, the PCL/Gel/IL-4 scaffold markedly promoted the osteogenesis of bone marrow mesenchymal stem cells, which was demonstrated by increased alkaline phosphatase activity and enhanced deposition of mineralized nodules. Moreover, it induced a shift in macrophage polarization to the M2 phenotype, accompanied by elevated expression of the anti-inflammatory mediators Arg-1 and IL-10 and downregulating pro-inflammatory genes. These results demonstrate that the PCL/Gel/IL-4 membrane synergistically improves physical properties, release behavior, osteogenic capacity, and immunomodulation, offering a promising multi-functional platform for bone regeneration.
Guofeng Huang, Min Liu, Zhiyuan Tai et al.· Materials Research Express· 0 citations
In vivo results further demonstrated that CCH hydrogel patches accelerated wound closure, improved healing quality, and attenuated scar-like changes in mice, providing a promising biomaterial strategy for high-quality repair of complex skin wounds.
Jiahao Ji, Jiamin Ni, Fei Chang et al.· Frontiers in Bioengineering...· 0 citations
The findings suggest that nanofiber wound dressings formulated with nanoscale materials represent a promising and effective alternative to conventional wound dressings, particularly for the therapeutic management of injuries associated with chemical, biological, radiological, and nuclear(CBRN) incidents.
N. Tufan, Halis Uğuz, S. Karakurt· Polymer Bulletin· 0 citations
The integration of electroresponsive materials, natural bioactive constituents, and electrical stimulation provides a promising multifunctional platform for electrically assisted wound management.
Zhong-Xiang Tang, Bin Wu, Ying-Jia Shi et al.· Polymer Bulletin· 0 citations