Ahead of the membrane curve: in silico insights into amyloid-β aggregation

Open access Aug 2026

Membrane Complexity and Phase Behavior Dictate the Stability of Membrane‐Inserted Aβ 42 Hexamers

It is demonstrated how membrane complexity and phase behavior dictate the stability of toxic Aβ42 oligomers, offering key insights into the membrane‐mediated mechanisms of neurotoxicity.

Bastian F. Bundschuh, Franziska Kley, Yu Wang et al. · ChemPhysChem · 0 citations

#protein folding Sep 2026

Discriminating Monomers and Fibrils of Amyloid-β1-42 With Site-Ordered Peptide-QMFluors.

The detection of soluble amyloid-β (Aβ), the most neurotoxic species in early Alzheimer's disease (AD), remains a major analytical challenge. Conventional probes are designed to target the β-sheet structures of mature fibrils and are thus blind to these transient, nonfibrillar species. Here, we introduce "site-ordered...

Rui-Long Dai, Jian-Feng Dai, Chen-Xu Yan et al. · Angewandte Chemie · 0 citations

Sep 2026

Exploring the thermodynamic competition between APP C99 dimerization and membrane partitioning in model liquid-ordered and disordered membranes.

Lateral membrane heterogeneity creates distinct lipid environments that modulate both the localization and association of transmembrane proteins. Previous studies have examined how transmembrane proteins partition between ordered and disordered domains, and separate studies have shown that membrane composition can modu...

Sangram Prusty, Ayan Majumder, John E. Straub · Journal of Chemical Physics · 0 citations

Open access Sep 2026

Membranes Decouple α-Synuclein Surface Assembly and Kinetic Restriction from Persistent Amyloid-like Intermolecular Organization

Membrane association places α-synuclein (αSyn) at the boundary between physiological surface organization and pathological amyloid assembly, supporting vesicle clustering, surface condensation, and amyloid nucleation. How interfacial recruitment, condensate cohesion, and persistent amyloid-like organization are coupl...

Jin-Yu Chen, Xia-Kun Chu · JACS Au · 0 citations

Open access Sep 2026

Microfluidic confinement enables monitoring of oligomeric forms of 1-40 β-amyloid peptide in kinetic study by AFM.

Amyloid aggregates are hallmarks of a variety of pathologies. The amyloid beta (A-β), aggregates are critical actors in the pathophysiological process of Alzheimer's disease (AD). Understanding their mechanism of growth at the early stages, in terms of intermolecular and environmental factors, may help to identify crit...

P. Greco, A. Lazar, F. Lugli et al. · Journal of Colloid and Inter... · 0 citations

Sep 2026

Rosmarinic Acid Inhibits β-Sheet and β-Hairpin Formation in Human Islet Amyloid Polypeptide Dimers by Stabilizing Localized C-Terminal Motifs: An REMD Study

The misfolding of human islet amyloid polypeptide (hIAPP) into soluble oligomers is a primary pathological event in type 2 diabetes, with the early dimerization process representing a critical pharmacological target. Here, we investigate the molecular mechanism by which rosmarinic acid (RA) counteracts full-length hI...

Gang Wang, Xin-Qiu Zhu, Zi-Qian Zhao et al. · ACS Chemical Neuroscience · 0 citations