A comprehensive and up-to-date review of the current knowledge in circRNAs is provided, as well as to discuss the potential of circRNAs as biomarkers for NSCLC detection and assessment, alongside the limitations associated with their clinical applications.
Abstract
Simple Summary Circular RNAs (circRNAs) represent a novel and important class of endogenous, mainly non-coding RNAs, which result from pre-mRNA back-splicing. CircRNAs are now well-recognized as critical contributors to various cancer cell hallmarks in different types of cancer, including lung cancer. However, their involvement in the reshaping of the tumor microenvironment, more particularly the tumor immune microenvironment, and the development of resistance to therapies remains less explored, notably in non-small cell lung cancer (NSCLC). Here, we aim to provide a comprehensive and up-to-date review of the current knowledge in this still-emerging research field, as well as to discuss the potential of circRNAs as biomarkers for NSCLC detection and assessment, alongside the limitations associated with their clinical applications.
Non-coding RNAs serve as key regulators of gene expression at both the transcriptional and post-transcriptional levels. Among them, piRNAs, a class of small non-coding RNAs, have emerged as significant mediators in cancer biology. PIWI proteins, members of the Argonaute family highly expressed in germline cells, intera...
A. Nakhaei, A. Omidkhoda, Farzaneh Abbasinezhad-Moud et al.· Iranian Journal of Basic Med...· 0 citations
This Review explores the dual roles of lncRNAs as oncogenes or tumour suppressors, their involvement in immune modulation, vascular remodelling and extracellular matrix dynamics, and their involvement in immune modulation, vascular remodelling and extracellular matrix dynamics.
M. Bartolini, F. Battaglin, S. Soni et al.· Nature reviews: Gastroentero...· 0 citations
Non-coding RNAs (ncRNAs) in tumor-educated platelets (TEPs) play an important role in cancer progression. Tumor cells can “educate” platelets, thereby enabling them to participate in multiple stages of tumor development and progression. The ncRNAs carried by TEPs, including microRNAs (miRNAs), circular RNAs (circRNAs),...
Ya-Ning Liu, Yu-Cheng Zhang, Dong-Ni Li et al.· Frontiers in Oncology· 0 citations
This review summarizes the diagnostic, prognostic, predictive, and therapeutic potential of tissue-derived, circulating, and exosomal miRNAs in NSCLC and discusses the major challenges limiting the clinical translation of miRNA-based biomarkers and therapeutics.
Imteyaz A. Khan, Surabhi Gupta, J. Meena· Journal of Human Genetics· 0 citations
Malignant tumors remain a leading cause of global mortality, and the development of chemoresistance represents a major obstacle to effective cancer treatment. Long non-coding RNAs (lncRNAs) are important regulators of tumor progression and therapeutic response. Cancer susceptibility candidate 2 (CASC2) is an lncRNA tha...
Ling-Yun Zhou, Jin-Tao He, Wen-Bing Huang et al.· Journal of chemotherapy· 0 citations
Improvements in elucidating the molecular mechanisms through which circRNAs influence the efficacy of breast cancer immunotherapy pave the way for improving the prognosis of breast cancer immunotherapy and open new avenues for future research and clinical translation.
Yu Jiang, Ya-Wen Wang, Kai Zhang· Frontiers in Immunology· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
