Defective synapto-nuclear signaling contributes to motoneuron vulnerability in SOD1-ALS

Dysregulation of cAMP-PKA-mediated mechanisms disrupts basal synaptic function in the absence of presynaptic FMRP

PKCα-deficient mice show altered synaptic signaling and impaired fear extinction

Findings identify PKCα as part of a signaling program associated with synaptic function and support a role for PKCα-dependent processes in adaptive updating of learned fear in Prkca-/- mice.

Pathogenic KIF1A variants differentially disrupt axonal trafficking and impede synaptic development

Functional analysis of neuronal activity reveals delayed synaptic maturation in loss-of-function mutations and insights into how KIF1A mutations with distinct molecular-level impacts lead to significant downstream synaptic deficits in human neurons.

Molecular and Cellular Mechanisms of Synaptogenesis and Synaptic Refinement During Cerebellar Circuit Formation

Together, coordinated molecular, cellular, and circuit-level mechanisms establish the synaptic architecture underlying cerebellar computation, motor coordination, and adaptive learning, which are the central focus of this review.

Presynaptic GABAB Signaling Enhances Synaptic Inhibition Without Mitigating Persistent Dentate Gyrus Hyperexcitability After Status Epilepticus

These findings support a disinhibitory role for presynaptic GABAB receptors, which bolsters synaptic inhibition to transiently counter post-SE hyperexcitability, and offers a targetable mechanism for therapeutic intervention during epileptogenesis.

RhoA in postnatal spinal motoneuron is essential for peripheral myelination

Peripheral myelination requires precise axon-glia communication, yet the neuronal intrinsic machinery that governs the release of axonal signals remains incompletely understood. Here, we discover that RhoA, a classic cytoskeletal regulator, is highly expressed in postnatal spinal motoneurons and unexpectedly governs th...