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Dose-dependent effects of fingolimod on behavioral, molecular, and Stereological outcomes in a rat model of intracerebroventricular streptozotocin-induced Alzheimer’s disease-like cognitive dysfunction

Alireza Khani-Robati Mohammad Banizaman Farima Jahromi Maryam Porsadeghfard E. Rafiei Sachchida Nand Rai Amirhossein Yousefi Nejad S. Akbari Maryam Naseh M. Bayat Mohammad Saied Salehi M. Haghani Bijan Akbarpour Etrat Hooshmandi

Aug 2026 · 3 Biotech · Vol 16 · 0 citations · 96 references

Medicine

TL;DR

Fingolimod exerted dose-dependent, domain-specific effects, with lower doses improving functional outcomes and the intermediate dose providing greater preservation of hippocampal structure, suggesting beneficial effects within the doses examined.

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