Formononetin Attenuates Seizure Severity and Cognitive Deficits in PTZ-Kindled Rats with Associated Changes in Oxidative Stress and P2 X 7/IL-1β/Glutamate Signalling Markers

Open access Jul 2026

Impact of Imipenem on Cognitive Function, Anxiety-like Behaviour, Neurogenesis, and Astrogliosis in Pentylenetetrazol-Kindled Rats

It is suggested that imipenem modulates the cellular substrate of the pre-sensitized brain, interfering with hippocampal plasticity and glial compensatory mechanisms, rather than directly driving further behavioural deterioration.

Leonardo Araújo-Andrade, Pedro Nogueira, Bárbara Caetano-Mota et al. · Antibiotics · 0 citations

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Open access Sep 2026

Lamotrigine Attenuates Lipopolysaccharide-Induced Working-Memory Impairment and Is Associated with Changes in Neuroinflammatory, Oxidative-Stress, and Apoptosis-Related Markers

Highlights What are the main findings? Lamotrigine (LTG) ameliorated lipopolysaccharide (LPS)-induced working-memory impairment and suppressed neuroinflammatory responses in the prefrontal cortex. LTG reduced oxidative stress and pro-apoptotic signaling while restoring endogenous antioxidant and anti-apoptotic defenses...

Bashair Hamed Alharbi, A. A. A. Alshammari, V. Mani · Brain Science · 0 citations

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Jul 2026

Trigonelline attenuates valproic acid-induced autism-like behaviours in rats: histopathological changes of the hippocampus, modulation of gene expressions related to neuroinflammation and blood-brain barrier permeability.

Investigation of Trigonelline's effects on autistic phenotype, gene expression of tight junction proteins associated with BBB integrity, neuroinflammation and histopathological changes in the hippocampus in valproic acid - induced autism in rats found it significantly attenuated autistic behaviors.

Zahra Forouzandeh Shahraki, A. Noori, Hossin Amini-Khoei et al. · World Journal of Biological... · 0 citations

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Open access Aug 2026

Carvedilol attenuates PTZ-induced epileptogenesis: associations with hippocampal neuroinflammation and PI3K/AKT/mTOR-related alterations

Findings demonstrate associations between carvedilol treatment and multiple pathological processes during PTZ-induced kindling, but do not establish direct pathway-specific causality.

Ahmed H. Madkour, Rania R. Abdelaziz, Manar A. Nader et al. · Scientific Reports · 0 citations

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Open access Aug 2026

Dose-dependent effects of fingolimod on behavioral, molecular, and Stereological outcomes in a rat model of intracerebroventricular streptozotocin-induced Alzheimer’s disease-like cognitive dysfunction

Fingolimod exerted dose-dependent, domain-specific effects, with lower doses improving functional outcomes and the intermediate dose providing greater preservation of hippocampal structure, suggesting beneficial effects within the doses examined.

Alireza Khani-Robati, Mohammad Banizaman, Farima Jahromi et al. · 3 Biotech · 1 citation

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Open access Sep 2026

Resveratrol’s Neuroprotective Effects on the Retina in a Pentylenetetrazol-Induced Epilepsy Model in Rats: Insights into SIRT1 Signaling, Apoptosis, and Gliosis

Preclinical findings suggest that Resveratrol represents a promising protective strategy against epilepsy-associated retinal damage, though further clinical validation is warranted to establish its therapeutic safety and efficacy in human patients.

O. Unal, N. Akgun-Unal, Elif Gulbahce-Mutlu et al. · Antioxidants · 0 citations

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