ASSESSMENT OF THE BIO- STIMULATORY IMPACT OF T-PRF COMPARED TO T-PRF AUGMENTED WITH DIODE LASER IN DENTAL IMPLANTS FOR THE REPLACEMENT OF POSTERIOR MANDIBULAR TEETH: A RANDOMIZED CONTROL TRIAL
Aug 2026· Genetics and Molecular Research· 0 citations· 9 references
TL;DR
Adjunctive use of LLLT with T-PRF effectively reduced early postoperative pain but did not provide significant additional benefits regarding implant stability or bone density compared with T-PRF alone.
Abstract
Background: Successful dental implant therapy primarily depends on osseointegration, a biological process involving sequential bone healing and remodeling around the implant surface. Bio-stimulatory approaches such as Titanium Prepared Platelet Rich Fibrin (T-PRF) and Low-Level Laser Therapy (LLLT) have gained attention because of their potential to enhance tissue regeneration, improve implant stability, and accelerate healing. Aim: To assess and compare the bio-stimulatory impact of T-PRF alone and T-PRF augmented with diode laser therapy in dental implants placed for replacement of posterior mandibular teeth. Materials and Methods: This prospective randomized controlled clinical trial included 50 patients with unilateral posterior mandibular edentulous spaces requiring implant-supported rehabilitation. Patients were randomly allocated into two equal groups: Group A received T-PRF alone, whereas Group B received T-PRF combined with LLLT. Implant stability was assessed using Resonance Frequency Analysis and Implant Stability Quotient (ISQ) values at baseline, 3 months, and 6 months. Bone density was evaluated using Cone Beam Computed Tomography (CBCT), while postoperative pain was assessed using Numerical Rating Scale (NRS) scores at different postoperative intervals. Statistical analysis was performed using SPSS software with p<0.05 considered statistically significant. Results: Both groups demonstrated progressive improvement in implant stability and peri-implant bone density during follow-up. The T-PRF + LLLT group showed lower postoperative pain scores compared with T-PRF alone, with a statistically significant difference observed on postoperative Day 2 (p<0.05). However, no statistically significant differences were observed between groups regarding implant stability or bone density. Conclusion: Adjunctive use of LLLT with T-PRF effectively reduced early postoperative pain but did not provide significant additional benefits regarding implant stability or bone density compared with T-PRF alone.
T titanium-reinforced d-PTFE membranes may offer mechanical advantages in space maintenance and dimensional stability, particularly in larger vertical defects; however, the available comparative evidence did not demonstrate a consistent statistically significant superiority over collagen-based approaches.
Chloé Duchatelle, Rosana Costa, Ana Sofia Vinhas et al.· Journal of Functional Biomat...· 0 citations
Introduction: This study aimed to compare implant stability and crestal bone loss between titanium platelet-rich fibrin (T-PRF)-treated implants and conventional implants. Methods: A prospective, randomized, split-mouth clinical trial was conducted in 10 healthy patients, with 20 implants per mouth (test and control). Each patient received one T-PRF-treated implant and one conventional implant. Implant stability was assessed using implant stability quotient (ISQ) at placement and at 3 months. Crestal bone loss was evaluated radiographically at 3 and 6 months. Soft tissue parameters were assessed at follow-up visits. Results: The T-PRF group showed higher ISQ values and reduced bone loss, with trends favoring the intervention at the three-month follow-up compared with the control group. Bone loss at three and six months was lower around anterior implants in the T-PRF group than in the control group. At this time, T-PRF may help improve soft tissue measurements; however, the measured values did not differ significantly from those of the control groups. Due to limitations such as a small sample size, a relatively short follow-up period, and varying baseline crestal bone levels, these findings should be interpreted with caution. Conclusion: Due to the restrictions of this split-mouth study, T-PRF-treated sites showed a trend towards increased early implant stability and decreased crestal bone loss compared to control sites. However, because of the small sample size and short follow-up period, conclusive evidence cannot be drawn about the clinical superiority of T-PRF. Further appropriately powered randomized controlled trials with prolonged follow-up periods are necessary to determine the long-term clinical efficacy of T-PRF in implant therapy. Clinical Trial Registration number: CTRI/2022/11/047159.
Anuraga Tejaswi Thotimpuri, M. Pasupuleti, G. Penmetsa et al.· Journal of Advanced Periodon...· 0 citations
Neither the choice of drilling technique nor the implant macrogeometry significantly influences insertion torque or stability levels in regions of low bone density in this randomized controlled clinical study.
Worood A Akram, S. Bede· The Journal of craniofacial...· 0 citations
PURPOSE
Healthy peri-implant soft tissues are essential for implant longevity. Low-level laser therapy (LLLT) has emerged as a promising additional approach for enhancing wound healing after implant surgery, but evidence remains inconsistent. This study evaluates the clinical, radiographic, and inflammatory effects of LLLT on peri-implant soft tissue healing, pain, inflammatory biomarkers, and marginal bone preservation following implant placement.
MATERIALS AND METHODS
This randomized, controlled, single-blinded trial included 272 adults requiring single-tooth implants. Participants were randomized to two equal groups, LLLT (n=136) or control (n=136). The intervention involved daily 810 nm diode laser irradiation for five days post-surgery. Outcomes assessed included pain (VAS), healing clinical indices, oral health-related quality of life (OHIP-14), marginal bone loss (MBL), and peri-implant crevicular fluid biomarkers. Statistical analysis was conducted using SPSS software with mixed-effects models adjusted for baseline imbalances.
RESULTS
Among 272 participants, baseline demographics and comorbidities were comparable (all p>0.23 and p≥0.658, respectively). LLLT significantly reduced pain scores across all follow-ups (0.35-1.21 points lower, partial η²=0.783) and improved healing indices, gingival inflammation, and bleeding scores compared to controls. The LLLT group demonstrated persistently lower peri-implant inflammatory markers (TNF-α) and higher angiogenic response (VEGF). Radiographic evaluation revealed less MBL in the LLLT group with 0.07-0.22 mm less than control after day 7. Additionally, patients reported improved oral-health-related quality of life.
CONCLUSION
LLLT enhances peri-implant wound healing, reduces pain and inflammation, and preserves marginal bone, suggesting its value as a minimally invasive adjunct to implant therapy.
Shangtong Sun, Miaomiao Yang, Kui Zhang et al.· The International Journal of...· 0 citations
In edentulous maxilla with insufficient bone width, both the association of i-PRF+DBBM and DBBM alone were effective in providing bone width gain for implant placement, and the association of DBBM with i-PRF showed similar outcomes compared with DBBM alone for the studied parameters.
Gabriel Rodrigues Oliveira, Vínicius Fabris, Alfonso Sánchez-Ayala et al.· Clinical Oral Investigations· 0 citations
Background: Prolonged orthodontic treatment duration remains a major clinical concern because of its association with root resorption, enamel decalcification, periodontal complications, and reduced patient compliance. Injectable platelet-rich fibrin (I-PRF), a second-generation autologous platelet concentrate rich in growth factors and inflammatory mediators, has recently gained attention as a minimally invasive adjunct for accelerating orthodontic tooth movement (OTM). Aim was to evaluate the effectiveness of I-PRF on the rate of OTM during maxillary canine retraction.
Methods: This prospective split-mouth clinico-experimental study included nine patients requiring bilateral maxillary first premolar extractions for orthodontic treatment. The right maxillary quadrant received intraligamentary I-PRF injections, while the contralateral side served as the control. Canine retraction was performed using nickel-titanium closed-coil springs delivering 150 g force on 0.019″×0.025″ stainless steel archwires. I-PRF was prepared using low-speed centrifugation at 700 rpm for 3 minutes and administered at baseline and eighth week. OTM was evaluated monthly for three months using three-dimensional digital model superimposition. Statistical analysis included paired t-test, repeated measures ANOVA, and Bonferroni post-hoc analysis.
Results: The I-PRF group demonstrated greater OTM compared to the control group at all evaluated intervals. Statistically significant differences were observed during the initial phase of retraction and in cumulative tooth movement from baseline to the third month. Repeated measures ANOVA revealed significant variation in tooth movement across different intervals in both groups.
Conclusions: I-PRF demonstrated a positive effect on accelerating OTM and may serve as an effective, minimally invasive biologic adjunct for enhancing orthodontic treatment efficiency.
Benezer Rapsang, Vaibhav Misra, A. Garg et al.· International Journal of Cli...· 0 citations
