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Plasma membrane PI4P recruits SNAP47 to mediate SNARE-dependent AMPAR exocytosis during synaptic potentiation

Jing Xi Shen Wang Deng Pan Yan-Rui Yang Ran-Ran Mao S. Lam Wenting He Guang-Hou Shui Yang Niu Lei Chen Cong Ma Jia-Jia Liu
Aug 2026 · bioRxiv · 0 citations
Biology

TL;DR

These findings reveal a mechanistic role for PI4P in mediating activity-dependent, SNARE-driven fusion of AMPAR exocytic vesicles with the PM, which is necessary for both LTP and long-term memory.

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