Acute Stress Drives Adaptive Anxiety via Excitatory-Inhibitory Imbalance in the Prefrontal-Amygdala Circuit in Male Mice.

Stress and medial prefrontal cortex: Sex-dependent effects in rodent models.

Implication of orexin transmission in chronic stress, hyperarousal, and neuroplasticity deficits: a mechanistic framework for depression and anxiety

Stress is a major risk factor for depression- and anxiety-related disorders and produces neuroplastic adaptations within brain regions that regulate emotion, cognition, and stress responsivity. These adaptations include dendritic retraction in the medial prefrontal cortex (mPFC), suppression of plasticity and neurogene...

An amygdala to anterior hypothalamic circuit gates stress sensitivity.

Previous adversity increases sensitivity to subsequent stressful events1-8, but the causal underlying changes in brain circuitry are poorly understood. Here we harnessed unbiased whole-brain activity mapping to identify circuits that are functionally remodelled by previous adversity to promote heightened stress sensiti...

A ventral hippocampus-prefrontal circuit mediates the pro-extinction effects of adult hippocampal neurogenesis on contextual fear.

BACKGROUND Adult hippocampal neurogenesis (AHN) contributes to hippocampal functions including contextual information processing and stress responses. Inhibiting AHN increases vulnerability to stress and hinders effects of therapeutic interventions for stress-related disorders, especially post-traumatic stress disorder...

Daily rhythms in fear extinction memory reflect structural and functional changes in a prefrontal-amygdala circuit

Circadian rhythms exert widespread influences on learning and memory processes across diverse brain regions. The extinction of emotional memories is enhanced when training and testing occur during the circadian active phase in both rodents and humans, yet the underlying neural mechanisms remain poorly understood. Here,...

The mPFC-reuniens-hippocampus pathway links brain circuitry and neural plasticity in antidepressant response

The pathophysiology of depression involves multiple biological processes, including circuit dysfunction and impaired neuroplasticity, yet an integrative view linking these processes remains elusive. Here, we identify a convergent circuit for antidepressant response and plasticity modulation. We demonstrate that chemoge...