PTPσ mediates the integration of grafted neuronal tissueoids with host neural pathways after complete spinal cord injury.

Rui Mao Yuan-Huan Ma Jinyuan Xiao Qing-Shuai Wei Yin-Chun Zhao Qi-Xing Hu Hou-ge Li Ke-Jun Zhang Lai-Jian Wang Hui-juan Shi Li Peng Jun-hua Wang Gui-Ling Chen Ying Liu B. Lai Ge Li Ying Ding Dong Zhou Lei Yin Yuan-Shan Zeng Xiang Zeng

Aug 2026 · Science China Life Sciences · 0 citations · 52 references

Medicine

TL;DR

E engineered human iPSC-derived neuronal tissueoids (Ntoids) in vitro revealed that the PTPσ-TrkC complex may participate in synaptic integration between transplanted neurons and host circuits, constituting a structural foundation for functional neural relay restoration in spinal cord injury repair.

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