Network pharmacology and molecular docking analyses were conducted to predict the relevant targets and signaling pathways and to explore the potential mechanisms of action.
Abstract
Chemical examination of Penicillium steckii HJT-A-10, an endophytic fungus derived from Rhodiola tibetica, led to the isolation of ten metabolites. Structural elucidation by spectroscopic methods revealed that two of these were previously unreported compounds (1 and 2), though the absolute stereochemistry of 2 remained provisional; the other eight isolates (3–10) were identified as known compounds. All ten metabolites were tested for their capacity to inhibit nitric oxide (NO) production in RAW 264.7 macrophages stimulated with lipopolysaccharide (LPS). Compounds 1–4 and 7–10 exhibited marked inhibitory effects. Among the two new compounds, 2 displayed stronger activity, with an IC50 value of 19.01 µM. To explore the potential mechanisms of action, network pharmacology and molecular docking analyses were subsequently conducted to predict the relevant targets and signaling pathways.
Eleven compounds (1–11), comprising two previously undescribed tetrahydrofuran derivatives (1–2) alongside nine recognized metabolites (3–11), were separated and purified from the EtOAc extract derived from the endophytic strain Aspergillus costaricensis. The structural determination of the compounds was achieved unamb...
Shao-Fei Teng, Kai-Ling Yang, Chen-Chen Sun et al.· Records of Natural Products· 0 citations
From the endophytic fungus Diaporthe phaseolorum associated with Polygonatum cyrtonema Hua, nine carboxamides were isolated, comprising five new compounds, phaseolorines A-E (1-3a, 4a, 6), along with four known compounds (3b, 5, 7, 8). Compounds 1-3 feature a rare 3-imidazolinozone structural unit, previously reported...
A chemical investigation of the CH2Cl2 extract of a sponge Agelas nakamurai guided by the molecular networking approach resulted in the isolation of 7 undescribed N-methylpurine diterpene alkaloids, namely nakamuranine A-G (1-7), in addition to (+)-8-epiagelasine T, agelasine D and (+)-agelamide D. Their structures wer...
Ruo-Feng Sun, Shang Chen, W. Cheng et al.· Bioorganic chemistry (Print)· 0 citations
Ten undescribed terpestacin-type sesterterpenoids, arthritacins A–J, together with five known analogues, together with five known analogues (11–15), were obtained from the endophytic fungus Arthrinium sp.
Xiao-Zheng Su, Kun Hu, Xing-Ren Li et al.· Journal of Fungi· 0 citations
Among them, compound 1 displayed the most potent anti-inflammatory activity, with an IC50 value of 9.05 ± 1.60 μM, comparable to that of the positive control dexamethasone.
Jing-Yi Yue, Yu-Jia Lu, Yang Yu et al.· Records of Natural Products· 0 citations
Abstract: A new compound, ingenol 3-O-β-D-glucopyranoside (1) was isolated from the roots of Euphorbia fischeriana Steud. (Euphorbiaceae), together with four known compounds (2−5). The structure of compound 1 was characterized by a combination of spectroscopic techniques and X-ray crystallography. Moreover, biological...
Ling-Ling Cai, En-Zhi Liu· Records of Natural Products· 1 citation
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