Synthesis, Crystal Structure, DFT, MEP, FMOs, Hirshfeld Analysis and Antitumor Activity Assay of 4-[(4-Fluorophenyl)amino]-6-pentylpyrido[4,3-d]pyrimidin-5(6H)-one

Enhancement of antitumor activity through structural optimization of 2-(Benzylamino)-thieno[2,3-d]pyrimidin-4(3H)-ones

Synthetic Strategies and Biological Activities of Pyrazolo[4,3-e]pyrrolo[1,2- a]pyrazines and Related Tricyclic Systems: A Comprehensive Literature Review.

Nitrogen-containing heterocyclic compounds with multiple fused rings have gained significant interest in medicinal chemistry due to their structural versatility and wide range of pharmacological applications. Within this category, pyrazolopyrrolopyrazines stand out as scaffolds featuring a tricyclic fused core composed...

Synthesis and characterization of selected new thiazolidine-2,4-diones derivatives: SwissADME and density-functional-theory analysis

All newly synthesized thiazolidine-2,4-dione derivatives showed encouraging therapeutic potential according to in silico studies, suggesting that they might be a possible therapeutic target.

Synthesis and evaluation of 3,5-disubstituted isothiazolo[4,5-b]pyridines, pyrazolo[4,3-b]pyridines and isothiazolo[3,4-b]pyrazines as inhibitors of PIKfyve

Various 3,5-disubstituted isothiazolo[4,3-b]pyridines were previously shown to be potent inhibitors of the lipid kinase PIKfyve, displaying broad-spectrum antiviral activity. To further study their structure-activity relationship and to discover novel skeletons as antivirally active PIKfyve inhibitors, a scaffold hoppi...

Design, synthesis, molecular docking and anticancer activity of novel N-(4-(chlorodifluoromethoxy)phenyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide derivatives

Results suggest that the N-(4-(chlorodifluoromethoxy)phenyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide scaffold is a useful template for designing selective BCR-ABL1-directed anticancer agents, with compound 9c as an encouraging lead for further optimisation and mechanistic studies.

Design, Synthesis, Characterization and Evaluation of Anticancer Activity of Substituted-4-(Substitutedphenylhydrazon o)-3,4-Dihydroquinolin-2-(1H)-One

The combined computational and biological data suggest that these hydrazinoquinoline derivatives, especially those with electron-withdrawing substituents, hold promise as lead structures for further development in liver cancer therapy targeting EGFR.