Gene therapy and genome editing technologies, including CRISPR-based methods, represent a transformative paradigm with the potential to achieve long-term or permanent correction of dyslipidemia, and these innovations expand therapeutic options, address residual cardiovascular risk, and advance lipid management toward precision and potentially curative strategies.
These agents have expanded treatment options for patients with familial dyslipidaemia, severe hypertriglyceridaemia, and persistent residual cardiovascular risk while paving the way for precision medicine.
Aryan Arora· Beyond the Pill – The Future...· 0 citations
Elevated low-density lipoprotein cholesterol (LDL-C) levels are an independent risk factor for the progression of atherosclerotic cardiovascular disease (ASCVD). Achieving substantial LDL-C reduction is recognized as a primary therapeutic goal, particularly for those at the highest risk of future cardiovascular events....
Dafsah Arifa Juzar, Sunanto Ng, I. Firdaus et al.· Indonesian Journal of Cardio...· 0 citations
INTRODUCTION: Cardiovascular diseases remain the leading cause of global mortality, with atherosclerosis as a central mechanism. Lipoprotein(a) [Lp(a)] is an independent and highly atherogenic risk factor associated with vascular inflammation and thrombosis. Statins do not reduce Lp(a) levels and may even increase them...
Laís de Barros Glaeser, Sofia Torres Velloso· Procedings of the 51st Congr...· 0 citations
Statins, ezetimibe, and PCSK9 inhibitors have enabled LDL-cholesterol to be lowered to levels previously thought very hard to achieve. However, even after achieving low levels, some patients continued to have cardiovascular events, a phenomenon known as residual cardiovascular risk. This phenomenon indicates the comple...
Mohammed Taha, Buraq Al-Ghaieb, Muntadher Al-Bulanee· American Journal of Cardiova...· 0 citations
As therapeutic options expand and agents with greater LDL-C reductions become available, personalized treatment strategies will become increasingly important to achieve LDL-C targets and may ultimately shift from stepwise intensification approaches toward early intensive treatment.
Eelke Houter, S. E. van den Bosch, B. Hutten et al.· Current Opinion in Lipidolog...· 0 citations
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