Yushida: an IoT-based smart injection system for long-term management of chronic diseases

Abstract

In the management of chronic diseases requiring long-term subcutaneous injections (such as pediatric short stature and chronic viral hepatitis), dosing accuracy and treatment adherence are critical factors affecting therapeutic efficacy. Pediatric populations, in particular, present unique physiological and behavioral challenges that demand stringent safety, precise dose accuracy, and robust adherence monitoring from injection devices. However, existing injection devices still exhibit notable limitations in tracking medication behavior, assessing adherence, and managing long-term treatment. This paper introduces Yushida (Xiamen Amoytop Biotech Co., Ltd.), an Internet of Things-based smart injection system, incorporating a concealed-needle cartridge, a sensing system, Bluetooth connectivity, voice guidance, and automatic data logging. The article systematically examines the device architecture and digital functionalities of the device and compares them with representative smart injection systems currently available. The potential clinical utility of the system and the challenges associated with its broader implementation are also discussed. Although quantitative evidence directly evaluating the clinical impact of Yushida remains limited, several prospective clinical and real-world studies are currently underway and are expected to further clarify its clinical utility. By providing a balanced assessment of current technologies and evidence, this paper seeks to offer an objective perspective on the future development of digitalized injection therapies.