ABCC6 in Cellular Metabolic Homeostasis: Biochemical Links to Extracellular Nucleotide Signaling, Mitochondrial Stress, and Senescence

Oxygen-dependent subcellular redistribution of PHD3 links the hypoxic microenvironment to mitochondrial metabolic reprogramming in ccRCC

Clear cell renal cell carcinoma (ccRCC) is characterized by profound metabolic dysregulation, with both prolyl hydroxylase domain protein 3 (PHD3) and pyruvate carboxylase (PC) independently implicated in disease progression. Although each influences patient outcomes, a direct mechanistic interplay between these two re...

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

Metabolic reprogramming is a hallmark of many human diseases, including cancer, metabolic dysfunction, cardiovascular disease, and chronic inflammation. By reshaping bioenergetic and biosynthetic pathways, cells adapt to environmental stress and altered functional demands. Acetyl‐coenzyme A (acetyl‐CoA) plays a pivot...

Mitochondrial metabolite transporters at the crossroads of metabolic reprogramming, epigenetic regulation and therapeutic vulnerabilities in colorectal cancer

Beyond Fuel: Metabolic Intermediates as Signaling Molecules in Neuroinflammation and Neurodegeneration.

Historically, research has viewed substantial brain metabolic activity through the lens of energy production, primarily treating metabolites as substrates and products in bioenergetic pathways. However, this paradigm is now evolving. Key metabolic intermediates are recognized not only as components of Adenosine Triphos...

AKAP1 orchestrates mitochondrial dynamics and metabolic reprogramming to promote hypoxia tolerance in yak cardiac fibroblasts.

High-altitude hypoxia poses a sustained energetic and oxidative challenge to the heart, often leading to mitochondrial dysfunction and metabolic inflexibility in nonadapted mammals. Yaks (Bos grunniens) exhibit remarkable cardiac tolerance to chronic hypoxia; however, the underlying intracellular mechanisms remain poor...

A PPARγ-like signalling axis integrates lipid homeostasis and mitochondrial quality control to preserve neuronal integrity

Peroxisome proliferator-activated receptor gamma (PPARγ) is a central regulator of lipid metabolism and a critical mediator of neuroprotection, yet the mechanisms linking these functions remain unclear. Here, we identify the Caenorhabditis elegans nuclear receptor SEX-1 as a functional PPARγ-like regulator and define a...