Integrated bulk and single-cell transcriptomic analyses identify senescence-related hub genes and microenvironmental remodeling in sarcopenia

Yan Chen Ke-Wen Ma Tian Huang Jing Gao Xiao-Dong Feng

Aug 2026 · Functional & Integrative Genomics · Vol 26 · 0 citations · 33 references

Medicine

TL;DR

PCK1, EGFR, and MAPKAPK3 are senescence-related candidate biomarkers in sarcopenia and may reflect distinct yet interconnected biological processes involving metabolic adaptation, stromal remodeling, immune microenvironment alteration, and myogenic dysregulation.

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