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Hexose-6-phosphate dehydrogenase deficiency disrupts hepatic fatty acid homeostasis and induces triglyceride accumulation

Gabriele Sakalauskaite S. Ebert J. Allard M. Zogg Isabel Meister J. Birk Alexander Schmidt J. Bouitbir A. Odermatt
Sep 2026 · bioRxiv · 0 citations · 1 references
Biology

TL;DR

The results indicate that H6PD plays an as-of-yet undescribed role in hepatic lipid metabolism, implying a link between the availability of NADPH within the endoplasmic reticulum and fatty acid homeostasis.

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