Co-administration of Staphylococcus aures Fibronectin Binding Protein A N1-3 region and Lipoteichoic acid antigen mixture enhance antibody response in BALB/c mice
This study evaluated the efficacy of two surface antigens of S. aureus -fibronectin-binding protein A (FnBPA) and lipoteichoic acid (LTA) as vaccine candidates and highlighted the potential of a multi-antigen vaccine strategy for preventing S. aureus infections.
Findings demonstrate that B. subtilis can serve as an effective platform for recombinant protein secretion and mucosal antigen delivery, supporting its application in vaccine development against S. aureus infection via mucosal route.
Hoa T. T. Vo, V. K. Phạm, Kiet Ngo et al.· Biotechnology Letters· 0 citations
ABSTRACT Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA) are ESKAPE pathogens that are responsible for severe skin and soft tissue infections (SSTIs), particularly in the elderly and those with immunocompromising conditions. Rising rates of methicillin-resistant S. aureus (MRSA) and carbapenem-resistant PA h...
Suhrid Maiti, T. Lu, Zackary Dietz et al.· Infection and Immunity· 0 citations
Urinary tract infections (UTIs) are highly prevalent across diverse populations, with uropathogenic Escherichia coli (UPEC) recognized as the leading cause, responsible for more than 85% of cystitis and acute pyelonephritis cases. Because bacterial attachment to the uroepithelium is the critical initial step in coloniz...
Meisam Akrami, M. Akrami, Amirhossein Amini et al.· Archives of Microbiology· 0 citations
Haemophilus influenzae is a Gram-negative bacterium that causes pneumonia, otitis media, and invasive infections such as meningitis and bacteremia. A vaccine that confers protection against disease caused by H. influenzae serotype b is currently available and is highly effective, but infections caused by non-b serotype...
Nikolas F. Ewasechko, David M. Curran, Luisa Samaniego-Barrón et al.· bioRxiv· 0 citations
Background Mycoplasma pneumoniae (Mp) remains a major cause of community-acquired pneumonia in children and adolescents, and no vaccine against this pathogen is currently available. This study designed and evaluated P1Tx, a novel multi-epitope vaccine candidate derived from the immunodominant regions of the P1 adhesin...
Peng-Xiao Feng, Rui Hu, Huan-Bing Long et al.· Frontiers in Immunology· 0 citations
Staphylococcus aureus employs a diverse repertoire of immune evasion proteins to escape host defenses. Formyl peptide receptor-like 1 inhibitory protein (FLIPr) is a secreted staphylococcal factor that targets both chemoattractant receptors and Fc gamma receptors (FcγRs) to suppress leukocyte activation and antibody-de...
Chen-Yi Chiang, Chia-Yu Chi, Yun-Ju Lee et al.· International Journal of Bio...· 0 citations
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