Paeoniflorin attenuates experimental autoimmune encephalomyelitis in mice in association with enhanced Treg differentiation and activation of Raf/MEK1/2/ERK1/2/Egr-1 signaling.

Xiao-Juan Zhang Ying-Ying Song Xinyan Han Meng-Xue Wang Yu-Feng Chen Yue Weng Ya-Xin Li Fei Huang Hai-Lian Shi Hui Wu Xiaojun Wu

Sep 2026 · Naunyn-Schmiedeberg's Archives of Pharmacology · 0 citations · 42 references

Medicine

TL;DR

Results indicate that PF treatment is associated with modulation of the Treg/Th17 balance in EAE mice and with changes in Raf/MEK1/2/ERK1/2/Egr-1 signaling in Jurkat cells, indicating a significant neuroprotective effect.

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