2026· International review of neurobiology· Vol 188, pp.
67-89
· 2 citations
Medicine
TL;DR
Cerebral bioenergetic metabolic failure as a central driver of cognitive decline, arising from irreversible reactive gliosis and neuroblastosis mechanisms is emphasised and various therapeutic options are highlighted, including restoration of ANLS to mitigate the pathogenesis and memory loss in AD.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterised by progressive loss of motor neurons. In addition to neurodegeneration, ALS is increasingly recognised as a disorder associated with widespread metabolic dysfunction, including hypermetabolism, weight loss, and dyslipidaemia, all of...
Áine Heffernan, Florence Do, Eleanor D. Carter et al.· Frontiers in Cell and Develo...· 0 citations
Alzheimer’s disease (AD) is characterized by cerebral glucose hypome-tabolism, an early hallmark through neuroimaging and neuropathological investigations. Previous researches have established the phenomenon of reduced glucose uptake. Building upon this established knowledge, the field is now increasingly focused on el...
Min-Min Chen, Chang-Min Zuo, Run-Zhi Li et al.· Discover Neuroscience· 0 citations
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