Various categories of biomarkers, including protein aggregates, inflammation-related factors, oxidative stress markers, metabolomic and lipidomic signatures, genetic and epigenetic status, and PD-related exosomes are discussed, could serve as a diagnostic tool for PD and may provide predictive measures of disease outco...
Jerly Helan Mary Joseph, Mahesh Kandasamy· International review of neur...· 0 citations
The blood-based biomarkers represent a transformative step toward early diagnosis, large-scale screening, and precision medicine in AD, with significant potential for the development of disease-modifying therapies.
Greata Rubavathi Eliazer, Mahesh Kandasamy· International review of neur...· 0 citations
Cerebral bioenergetic metabolic failure as a central driver of cognitive decline, arising from irreversible reactive gliosis and neuroblastosis mechanisms is emphasised and various therapeutic options are highlighted, including restoration of ANLS to mitigate the pathogenesis and memory loss in AD.
Gowsika Baskar, Mahesh Kandasamy· International review of neur...· 2 citations
Insight into the scientific concepts that interrelate the pathophysiology of schizophrenia with astroglia dysregulation at the level of gliotransmitter imbalance could provide innovative hints for developing therapeutic strategies for the treatment of schizophrenia.
Mercy Priyadharshini Babu Deva Irakkam, Mahesh Kandasamy· International review of neur...· 0 citations
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