2026· International review of neurobiology· Vol 188, pp.
91-112
· 0 citations
Medicine
TL;DR
Insight into the scientific concepts that interrelate the pathophysiology of schizophrenia with astroglia dysregulation at the level of gliotransmitter imbalance could provide innovative hints for developing therapeutic strategies for the treatment of schizophrenia.
A comprehensive understanding of neuroinflammatory mechanisms may provide new opportunities for developing targeted therapeutic interventions and improving clinical outcomes in psychiatric disorders, including patient stratification and enable precision psychiatry.
P. Karwa, Vaibhav Parekar, Sarthak Buttepatil et al.· Current pharmaceutical desig...· 1 citation
Emerging therapeutic strategies targeting microglia were discussed, including anti-inflammatory approaches, functional reprogramming, neuromodulation techniques, and microglial replacement or niche engineering, indicating a paradigm shift from indiscriminate microglia inhibition to the precise modulation of specific fu...
J. R. de Jesus, I. S. Ribeiro, Marcos V. S. Pereira et al.· Advances in Immunology· 0 citations
This review systematically summarizes current research on astrocyte involvement in PD pathology and their neuronal interaction mechanisms, further exploring their interconnections to elucidate disease pathogenesis.
Yifan Li, Qiang Li, Yemin Wang et al.· Journal of physiology and bi...· 1 citation
These findings link KYNA to excessive, activity-dependent synaptic elimination in human cellular models of schizophrenia and show that its dynamics are sensitive to immune signaling.
F. Orhan, P. Fridh, S. Djurovic et al.· International Journal of Neu...· 0 citations
Neurodegenerative diseases are a heterogeneous group of chronic and progressive disorders, which are characterized by selective neuronal destruction, synaptic malfunction and progressive cognitive and locomotor dysfunction. The major ones are Alzheimer disease, Parkinson disease, Huntington disease, and amyotrophic lat...
Nisha, Sumairah Qadir· Current Pharmaceutical Resea...· 0 citations
In conclusion, altered glutamatergic neurotransmission represents a central mechanism in PTSD pathophysiology and its role in synaptic plasticity, neuronal vulnerability, and network dysregulation highlights its potential relevance as a diagnostic and therapeutic target.
E. Ogłodek· Polski merkuriusz lekarski :...· 0 citations
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