2026· Advances in Immunology· Vol 171, pp.
371-400
· 0 citations
Medicine
TL;DR
Emerging therapeutic strategies targeting microglia were discussed, including anti-inflammatory approaches, functional reprogramming, neuromodulation techniques, and microglial replacement or niche engineering, indicating a paradigm shift from indiscriminate microglia inhibition to the precise modulation of specific functional states.
A comprehensive understanding of neuroinflammatory mechanisms may provide new opportunities for developing targeted therapeutic interventions and improving clinical outcomes in psychiatric disorders, including patient stratification and enable precision psychiatry.
P. Karwa, Vaibhav Parekar, Sarthak Buttepatil et al.· Current pharmaceutical desig...· 1 citation
Neurodegenerative diseases are a heterogeneous group of chronic and progressive disorders, which are characterized by selective neuronal destruction, synaptic malfunction and progressive cognitive and locomotor dysfunction. The major ones are Alzheimer disease, Parkinson disease, Huntington disease, and amyotrophic lat...
Nisha, Sumairah Qadir· Current Pharmaceutical Resea...· 0 citations
Insight into the scientific concepts that interrelate the pathophysiology of schizophrenia with astroglia dysregulation at the level of gliotransmitter imbalance could provide innovative hints for developing therapeutic strategies for the treatment of schizophrenia.
Mercy Priyadharshini Babu Deva Irakkam, Mahesh Kandasamy· International review of neur...· 0 citations
Depression is a highly heterogeneous disorder involving diverse biological systems and pathogenic pathways. Clinical and prospective studies have revealed that a substantial proportion of patients present with elevated peripheral and central inflammatory cytokines, a phenotype strongly associated with poor response to...
Fei Ye, Shu-Qin Qiu, Yun-Qing Chen et al.· Brain, behavior, and immunit...· 0 citations
Intervention strategies that shift from targeting peripheral immune and glial cells to regulating neuron-derived immunity are systematically integrated, thereby providing a new theoretical framework for overcoming current clinical limitations and identifying effective therapeutic targets for the prevention and treatmen...
Jie Bu, Xuan Nie, Haiting Luo et al.· Pharmacological Research· 0 citations
This synthesis synthesizes multimodal evidence from human neuroimaging, post-mortem tissue analysis, clinical cohorts, and preclinical animal studies to delineate the distinct regulatory logics governing peripheral and cerebral iron metabolism, and constructs a unified mechanistic framework illustrating how diverse eti...
