Two human monoclonal antibodies, 5217-2 and 5217-9, are identified and characterized, which bind recombinant PIV3 HN protein, bind PIV3-infected cells, and are neutralizing in vitro and demonstrate new protective mAbs for both PIV3 and PIV1.
Pneumoviruses cause seasonal outbreaks leading to hospitalizations of vulnerable populations such as infants and the elderly. Cross-neutralizing antibodies targeting viral fusion have been isolated from infected individuals, but their elicitation and mechanisms of action remain understudied. Here, we describe two vacci...
S. Ols, Rodrigo Arcoverde Cerveira, A. J. Borst et al.· bioRxiv· 0 citations
Human parainfluenza viruses (HPIVs) can cause severe respiratory illnesses, such as croup, bronchiolitis, and pneumonia, particularly in children, the elderly and immunocompromised individuals. No vaccines or specific therapeutics are available for use in humans. Here, we report the discovery of a human monoclonal anti...
A. De Marco, Risako Gen, Young-Jun Park et al.· bioRxiv· 0 citations
This study identifies a novel, highly conserved with conservative substitutions linear B-cell epitope on the RABV glycoprotein, providing a precise molecular target for the rational design of next-generation epitope-based vaccines and specific diagnostic tools.
Yu-Mei Chen, Xiao-Hui Zhang, Yan-Hua Qi et al.· Medical Microbiology and Imm...· 0 citations
ABSTRACT Influenza B viruses contribute substantially to seasonal disease burden; however, the structural basis by which antibodies recognize the major glycoprotein hemagglutinin (HA) and mediate antiviral activity remains incompletely defined. Influenza B virus used to circulate as two antigenically distinct lineages,...
D. Bhavsar, Alesandro Civljak, Bruno Bonnettaz et al.· Journal of Virology· 0 citations
ABSTRACT The continuous antigenic drift of zoonotic H7 avian influenza viruses remains a significant global public health threat. While monoclonal antibodies (mAbs) targeting the hemagglutinin (HA) head offer potent neutralization, their efficacy is often undermined by rapid viral escape. In this study, we systematical...
Han Wu, Fan Yang, Ping Wang et al.· Emerging Microbes and Infect...· 0 citations
This work clarifies the molecular basis of PRV neutralization and identifies a conserved epitope, which upon further validation could serve as a diagnostic candidate and inform antiviral research.
Yu-Mei Chen, Jie Gao, Rui-Rui Liu et al.· Archives of Microbiology· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
