TL;DR
At the 20-year follow-up, individuals in the Functional recovery trajectory demonstrated the most favorable outcomes, while those in the Impaired functioning trajectory exhibited the poorest outcomes across all key domains.
Findings highlighted the importance of tracking functional changes during the initial years of illness, and identified four distinct trajectories, including persistently-good class, gradually-improved class, suboptimal-stable class, and persistently-poor class.
BACKGROUND AND HYPOTHESIS Cognitive impairment is a core feature of psychotic disorders and predicts long-term outcomes. However, cognitive trajectories following first-episode psychosis (FEP) are heterogeneous. We hypothesized the presence of distinct global and domain-specific cognitive trajectories over two years, w...
Sustained hyperkinetic severity was consistently associated with poorer verbal memory and functional outcome over time, supporting the relevance of MAs as longitudinal correlates of cognitive and functional variability in early psychosis.
BACKGROUND Late-life depression (LLD) is often accompanied by functional limitations, which may persist after symptomatic improvement, increasing relapse risk. Care for functional limitations in LLD is difficult, as they vary across different domains and are linked to both depression and aging. This study identified si...
BACKGROUND Positive and negative symptoms are considered core features of psychotic disorders. However, no study has identified joint trajectories of positive and negative symptoms in early psychosis with long-term follow-up. METHOD We conducted 12-year follow-up of a randomized-controlled trial on extended early int...
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