TL;DR
The ‘proposed cardiac epigenetic scar’ – the continued disruption of chromatin-modifying enzymes that prevents metabolic recovery in heart failure patients despite mechanical unloading, a concept from human LVAD studies is introduced.
This narrative review examines how alterations in fatty acid oxidation, lipid uptake, cholesterol metabolism and lipid-derived metabolites converge on the sirtuin family of NAD+-dependent enzymes to regulate epigenetic states in cancer.
This comprehensive review synthesizes recent advances in lactate biology, encompassing the expanding enzymatic landscape of lactylation—including newly identified writers, erasers, and readers—and their roles in neurodegenerative diseases and critically re-examine metabolic coupling models beyond the classical astrocyt...
Histone methylation regulates chromatin structure and gene expression, whereas tumor metabolism provides bioenergetic and biosynthetic inputs. These processes are bidirectionally linked: S-adenosylmethionine supplies methyl groups for histone methyltransferases, α-ketoglutarate(α-KG) supports JmjC-domain demethylases,...
Lipid metabolism is no longer viewed simply as a source of membrane biomass or ATP. It is now proposed as a regulatory system that determines which metabolites reach the nucleus, which chromatin-modifying enzymes are engaged, and which transcriptional states become stable during disease progression. This review develop...
The distinctive contribution is an evidence-graded, falsifiable framework that links metabolic state to cell- and residue-specific lactylation while making explicit what remains to be demonstrated in human asthma.
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