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Sodium Butyrate Attenuates Renal Fibrosis by Regulating Glycolysis and Histone H4K12 Lactylation in Diabetic Kidney Disease

Ping He Ming-Xiu Wang Hang Mei Yue Liu Min Wang He Sun Yali Peng Xuan Ban Yue Wang Xiaofang Tang Qiu-Ling Fan
Aug 2026 · Diabetes, obesity and metabolism · Vol 28, pp. 9518 - 9534 · 0 citations · 52 references
Medicine

TL;DR

This study investigated the contribution of histone H4 lysine 12 lactylation to abnormal glycolysis and renal fibrogenesis in diabetic kidney disease (DKD) and evaluated sodium butyrate (NaB) as a potential therapeutic modulator.

Abstract

The role of histone lactylation in diabetes associated renal fibrosis remains poorly defined. In this study, we investigated the contribution of histone H4 lysine 12 lactylation (H4K12la) to abnormal glycolysis and renal fibrogenesis in diabetic kidney disease (DKD) and evaluated sodium butyrate (NaB) as a potential therapeutic modulator.

DOI PubMed Semantic Scholar
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