Aldosterone-renin ratio and plasma renin activity as biomarkers for treatment response in resistant hypertension

Aldosterone dysregulation in essential hypertension.

Aldosterone dysregulation is common in patients with essential hypertension and is associated with suboptimal blood pressure control, and currently available treatments may not fully address aldosterone dysregulation.

Plasma aldosterone and long-term myocardial remodeling: a 10-year prospective analysis from the Tanushimaru Cohort.

Resistant Hypertension: State of the Art Review.

Resistant hypertension, defined as blood pressure above target despite treatment with at least three antihypertensive agents (including a diuretic) or controlled blood pressure requiring four or more medications, affects over 140 million individuals globally and confers increased risks of heart failure, stroke, and chr...

Results from the Phase 2 Explore-CKD Trial of lorundrostat, a novel aldosterone synthase inhibitor, in participants with uncontrolled hypertension, chronic kidney disease, and albuminuria.

INTRODUCTION Dysregulated aldosterone plays an important role in the pathogenesis of hypertension (HTN) and chronic kidney disease (CKD). Lorundrostat, a highly selective aldosterone synthase inhibitor, has demonstrated efficacy and safety for uncontrolled HTN (uHTN) and treatment-resistant HTN in multiple well-control...

A comparative analysis on safety and efficacy of telmisartan and ramipril in treatment of hypertension in a tertiary care hospital

Background: Hypertension is a major global health challenge and an important risk factor for cardiovascular disease. Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are commonly used first-line antihypertensive agents. This study evaluated the safety and efficacy of telmisartan...

Cardiometabolic Renal Health Profile, Intensive Blood Pressure-Lowering Treatment and Cognitive Dysfunction: A Post Hoc Analysis of the SPRINT Trial.

BACKGROUND Whether participants with different cardiometabolic renal health profiles would derive comparable cognitive benefits from intensive blood pressure (BP)-lowering treatment remains underexplored. METHODS This post hoc analysis of the Systolic Blood Pressure Intervention Trial (SPRINT) derived a cardiometabol...