Aug 2026· Diabetes, obesity and metabolism· 0 citations· 18 references
Medicine
Abstract
Aims
To identify low- and high-risk intervals for major adverse cardiovascular events (MACE) and all-cause mortality according to lipid ratios in adults with Type 2 diabetes mellitus (T2DM), stratified by sex.
Materials And Methods
We used primary care electronic health records from the Spanish National Health Service including 303 199 adults with T2DM followed for a mean of 5.7 years (1.7 million person-years). Lipid indices were triglycerides/HDL cholesterol (TG/HDL-C), total cholesterol/HDL cholesterol (TC/HDL-C), non-HDL cholesterol/HDL cholesterol, LDL cholesterol/HDL cholesterol and the triglyceride-glucose (TyG) index. The outcome was a composite of all-cause mortality or hospitalisation for cerebrovascular or ischemic heart disease. Sex-specific Weibull models adjusted for clinical covariates were applied.
Results
U-shaped associations were observed between lipid ratios and outcomes. Increased risk was associated with higher ratios in both sexes, with slightly lower risk thresholds in women, while very low values were also linked to excess risk.
Conclusions
Extremes of lipid ratios were associated with higher cardiovascular risk, suggesting that moderate ranges may be protective. These easily obtainable markers may improve risk stratification and personalised prevention in T2DM care.
Dyslipidemia is a major contributor to adverse outcomes in patients with coronary heart disease (CHD) and type 2 diabetes mellitus (T2DM). The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is a comprehensive lipid marker, but its prognostic value in this high-risk populat...
Niuniu Wang, Xue-Jin Chen, Hao-Ran Li et al.· Medicine· 0 citations
In T2DM, LDL-C burden and variability jointly identified patients at greater risk, especially for MI and cardiovascular mortality, especially in younger adults or longer-duration diabetes subgroups.
Dae-Jeong Koo, J. Park, Kyungdo Han et al.· Diabetes, obesity and metabo...· 0 citations
OBJECTIVE
To assess cardiovascular disease (CVD) and all-cause mortality risk in patients with seropositive rheumatoid arthritis (RA) compared with matched controls, and examine whether low-density lipoprotein cholesterol (LDL-C) levels influence these risks.
METHOD
This nationwide retrospective cohort study used Kor...
J. H. Choi, J. Lee, C.-N. Son et al.· Scandinavian Journal of Rheu...· 0 citations
AIM
Low-density lipoprotein cholesterol (LDL-C) is a major contributor to atherosclerotic cardiovascular disease (CVD). The waist-to-height ratio (WHtR) has been proposed as a practical marker of central obesity; however, evidence linking WHtR with incident high LDL-C levels in Japanese populations remains limited. Thi...
Takako Fujii, Shintaro Ishida, Makiko Abe et al.· Journal of atherosclerosis a...· 0 citations
Introduction:Stroke is a leading cause of long-term disability and mortality worldwide, particularly in developing countries. Dyslipidemia, especially the triglyceride to high-density lipoprotein ratio (TG/HDL), and body mass index (BMI) play important roles in cardiovascular disease pathogenesis, including ischemic st...
Melfa Lamria Berliana Lumbantoruan, Sheilla Ayu Pricilia Wiedodo, Alif Caesar Rizqi Pratama· International Journal of Hea...· 0 citations
BackgroundElevated low-density lipoprotein cholesterol (LDL-C) is a well-established risk factor for coronary heart disease, but its role in stroke remains unclear. This study examined the association between LDL-C levels and the risk of cardiovascular disease (CVD) and its subtypes in a large cohort of Japanese worker...
Huan Hu, T. Nakagawa, T. Honda et al.· Journal of Epidemiology· 0 citations
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