The phenotype of SIK3C17TCKO mice closely resembles many features of polycystic ovary syndrome (PCOS), making it a valuable model for studying PCOS pathophysiology and potential treatments for ovulatory disorders.
Reproduction is one of the most fundamental biological processes in the human body, yet the molecules governing it remain incompletely understood. Here, we have characterized the role of PKHD1L1 and its globally relatively common splice donor variant rs17368310 in female fertility. We demonstrate estrogen-responsive ex...
E. Kapiainen, M. Karjalainen, P. Petrov et al.· medRxiv· 0 citations
Premature ovarian insufficiency (POI) is a heterogeneous disorder characterised by accelerated follicular depletion and ovarian dysfunction before age 40, yet effective therapeutic strategies remain limited. Here we identify the histone demethylase KDM3A (lysine‑specific demethylase 3A) as a critical protective factor...
Diminished ovarian reserve (DOR) leads to decreased ovarian endocrine function and reduced fertility in women, contributing to infertility. Dysregulated lipid metabolism can impair normal follicular development by interfering with cholesterol metabolism and hormone synthesis, thereby contributing to DOR. Farnesyl-dipho...
Xin Zhang, Peng Liu, Yun-Xiu Tan et al.· Journal of Steroid Biochemis...· 0 citations
It is demonstrated that miR-187 acts as a previously unrecognized regulator of early folliculogenesis and female reproductive capacity in medaka, expanding the repertoire of miRNAs with essential in vivo roles in teleost oogenesis and female fecundity.
Marlène Davilma, Stéphanie Gay, Manon Thomas et al.· Scientific Reports· 0 citations
The ovary ages earlier than most other organs, but the molecular mechanisms that drive this decline remain unclear. To gain more insight into this process, we profiled ovaries from young and reproductively aged mice after synchronized ovulation and found that aging was marked by the accumulation of luteal cells with in...
Liu-Bin Yang, Zhong-Wei Sun, Xin-Long Luo et al.· bioRxiv· 0 citations
Findings establish DHX36 as a maternal regulator that links oocyte intrinsic homeostasis to intercellular communication, suggesting that DHX36-dependent maintenance of membrane and organelle integrity is essential for OSF delivery, cumulus cell function, antral follicle development, and ovulation.
Yu-Xuan Jiao, Fangying Sun, Guo-Wei Bu et al.· bioRxiv· 0 citations
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