Aug 2026· Biomaterials Research· Vol 30· 0 citations· 33 references
Medicine
TL;DR
A nonferrous ferroptosis-like strategy employing 2D Ti3C2 MXene nanosheets is developed, combining enzymatic activity, photothermal effects, and immunomodulation to overcome TNBC resistance.
Abstract
Ferroptosis, a regulated cell death pathway driven by iron-dependent lipid peroxidation, has emerged as a promising strategy for cancer therapy. Nevertheless, the direct delivery of iron can lead to systemic toxicity. In this study, a nonferrous ferroptosis-like strategy employing 2D Ti3C2 MXene nanosheets was developed. The Ti3C2 nanozyme has been shown to possess peroxidase- and catalase-like activities, capable of decomposing H2O2 into cytotoxic·OH and O2, respectively. When exposed to near-infrared II laser irradiation, Ti3C2 induced a localized increase in temperature and amplified reactive oxygen species production, resulting in a synergistic effect that led to mitochondrial damage and glutathione peroxidase 4 inactivation. In vivo studies demonstrated tumor suppression in triple-negative breast cancer (TNBC) models, accompanied by M1 macrophage polarization and CD8+ T cell activation. This work provides a novel paradigm for nanocatalytic ferroptosis therapy, combining enzymatic activity, photothermal effects, and immunomodulation to overcome TNBC resistance.
The as-prepared iRGD-targeted nanoliposomes exhibit remarkable synergistic antitumor efficacy, inducing extensive tumor necrosis, apoptosis, and ferroptosis while causing minimal systemic side effects, demonstrating great application potential for future breast cancer therapy.
Runming Zhong, Ying-Zhe Wu, Yanzhen Lou et al.· Colloids and Surfaces B: Bio...· 0 citations
An upregulated GPX4 level of tumor cells with enhanced antioxidant defense systems accounts substantially for cisplatin resistance, but on the other hand, offers a unique therapeutic strategy due to the improved sensitivity of tumor cells to ferroptosis. Effective ferroptosis induction remains a challenge owing to insu...
Ying Liu, Zong-Tao Zhou, Wei Ma et al.· International journal of pha...· 0 citations
Ferroptosis is an iron-mediated cell death process driven by lipid peroxidation, yet its antitumor potential is often counteracted by the limited endogenous H2O2 content, the strict catalytic conditions required for the Fenton reaction, and protective autophagy. Notably, sustained autophagy drives ferritin degradation...
Chen-Shuo Wang, Zhen-Zhen Ma, Meng-Yu Liu et al.· European journal of pharmace...· 0 citations
Immune checkpoint inhibitors have shown limited efficacy in bladder cancer due to the immunosuppressive tumor microenvironment. To address this challenge, we developed a β-lapachone-loaded iron-based carbon nanozyme (C-MIL@Lapa) that synergistically induces ferroptosis and immunogenic cell death (ICD). Carbonized MIL-1...
Hong-Bo Luo, Xiao-Long Liu, Yang Du· Journal of Biomedical Materi...· 0 citations
A structurally reinforced ternary redox-cycling nanoreactor that integrates Zr4⁺-stabilized zeolitic imidazolate framework-8 with redox-active Cu/Mn centers and ultrasmall Au nanodots achieves sustained ROS amplification, iron-homeostasis remodeling, and enhanced tumor-selective ferroptosis, offering a promising therap...
Wan-mei Zhou, Zixin Wang, Chengdong Nie et al.· International journal of pha...· 0 citations
Cerium molybdate-doped polyaniline nanoparticles are developed to enable a synergistic combination of photothermal therapy (PTT) and CDT, thereby triggering immunogenic cell death (ICD) and enhancing antitumor immunity and presenting a robust nanoplatform integrating chemodynamic and photothermal therapies for potent c...
