TL;DR
Three techniques are described, surface plasmon resonance, protein microarray, and flow cytometry, to distinguish affinities of monoclonal antibodies specific to the Hen Egg Lysozyme, Ovalbumin, and Duffy (HOD) fusion model antigen.
Antigen-specific antibodies that bind to antigens play vital roles in adaptive immune defense; specifically, these are: Targeting and destroying bacteria, viruses, and other pathogens; forming immunological memory against previously encountered pathogens for future protection; diagnostic testing; and the development of...
This work will examine the development and use of B cell tetramers for the purpose of studying antigen-specific B cell responses following RBC transfusion.
Abstract Monoclonal antibodies (mAbs), engineered to recognize disease-associated antigens, are central to cancer immunotherapy due to their ability to block or eliminate malignant cells by engaging immune effector mechanisms. Yet many tumors evade or suppress these responses, limiting durable clinical benefit and high...
The protocols in this chapter outline the design, production, and evaluation of HLA-Fc proteins, emphasizing their efficacy in vitro and in immunodeficient mouse models, potentially providing new therapeutic approaches for managing HLA-sensitized patients in clinical practice.
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