Tectorigenin alleviates HFpEF by targeting the EGFR-EGR2-Acot1 axis to improve myocardial lipid metabolism.

Gentiopicroside Regulates EGFR and Induces Its Lysosomal Degradation to Attenuate Heart Failure.

Cardiac hypertrophy is a major pathological response to cardiovascular stress and a critical contributor to heart failure (HF). Gentiopicroside (GPS), a naturally occurring iridoid glycoside derived from Gentiana scabra, exhibits anti-inflammatory, antioxidant, and anti-fibrotic properties. However, its role and molecu...

Autotaxin Inhibition Ameliorates HFpEF Phenotype By Reducing LPA-Mediated Systemic Inflammation and Cardiac Remodeling

In male mice with established two-hit HFpEF, autotaxin inhibition improved diastolic indices and reduced fibrosis, hypertrophy and cardiac myeloid accumulation and the autotaxin–LPA axis is nominated as a tractable therapeutic target.

Hongqi Shenmai Decoction ameliorates post-myocardial infarction heart failure by preserving mitochondrial cardiolipin homeostasis via attenuation of EGFR/JAK2-STAT3 signaling.

BACKGROUND Post-myocardial infarction heart failure (post-MI HF) is driven by adverse ventricular remodeling and mitochondrial dysfunction. Cardiolipin is essential for mitochondrial integrity, but its upstream regulation in failing myocardium remains unclear. Whether Hongqi Shenmai Decoction (HQSMD) preserves cardioli...

Exploring the cardioprotective role of metformin against isoproterenol-induced myocardial infarction using computational, cellular, and animal models

Targeting PKGIα Cys42 attenuates cardiac dysfunction in heart failure with preserved ejection fraction

Heart failure with preserved ejection fraction (HFpEF) is a highly prevalent condition associated with substantial morbidity and mortality, yet effective therapeutic options remain limited. As oxidation of Cys42 in cyclic guanosine monophosphate (cGMP)-dependent protein kinase Iα (PKGIα) can enhance vessel and diastoli...

FGFR1/KLB-MFG-E8 Maintains Microvascular Integrity and Adaptive Cardiac Remodeling

BACKGROUND: Endothelial defects in the heart are a contributor to cardiac pathological remodeling and dysfunction, which can be influenced by cardiomyocytes. Here, we explore cardioprotective crosstalk between cardiomyocytes and endothelial cells under diabetic conditions. METHODS: Type 2 diabetes was induced in male a...