ZNF143 suppresses mitophagy to drive MASLD progression by regulating SMURF1/TRPV1 axis

NSUN4‐dependent m5C modification facilitates mitochondrial fission to accelerate diabetic nephropathy process via regulating SMURF1/CAMK1 axis

The discovery of the NSUN4/SMURF1/CAMK1 axis provides new insights into DN pathogenesis and promotes mitochondrial fission to accelerate DN progression via increasing CAMK1 ubiquitination.

Isoliquiritigenin ameliorates metabolic dysfunction-associated steatotic liver disease by modulating S100A8-associated MAPK signaling and ferroptosis-related processes

Findings support S100A8 as an important mediator of ISL's protective effects and provide a mechanistic basis for its potential application in MASLD.

TMEM189/PEDS1 deficiency aggravates MASH progression by promoting FASN-mediated macrophage activation

Transmembrane protein 189 (TMEM189), also known as plasmanylethanolamine desaturase 1 (PEDS1), is involved in plasmalogen biosynthesis, phospholipid metabolism, ferroptosis, and autophagy. However, whether TMEM189/PEDS1 regulates macrophages and disease-related inflammatory responses remains unclear. Here, we for t...

UBE2N deficiency contributes to MASH development via p62-regulated mitophagy and PANoptosis

NEDD4L-mediated ALYREF ubiquitination degradation suppresses RUBCNL expression to impair autophagy and promote lipogenesis in alcoholic hepatic fibrosis.

BACKGROUND Alcoholic hepatic fibrosis (AHF) is a progressive disease with limited therapeutic targets. This study investigated the role and mechanism of RUBCNL in AHF pathogenesis. METHODS The AHF mouse model was established using a chronic-plus-binge ethanol feeding protocol combined with CCl4 injection. Acetaldehyd...

NPAS2 promotes MASLD and hepatocarcinogenesis through SIRT1-mediated PPARγ suppression

Emerging evidence links circadian disruption to metabolic dysfunction-associated steatotic liver disease (MASLD), but the underlying mechanisms remain elusive. NPAS2, a core circadian regulator, has an undefined role in the pathogenesis of MASLD and its progression to hepatocellular carcinoma (HCC). This study aime...