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CFTR dysfunction in the intestinal epithelium is sufficient to promote pathogenic expansion of E. coli and enhanced barrier permeability in cystic fibrosis

Philip P. Ahern Naseer Sangwan Apollo Stacy Jessica M. Snyder Z. Johnson Megan Cua B. Chang Alexander Maynard Lauren Smith F. Sagl Brandon Bakos Akeem Santos Tina Nunn Anne-Marie C. Overstreet M. Wannemuehler S. Miller Jeannette S. Messer Mohammed Dwidar Mitchell L. Drumm C. Hodges A. Hajjar

Sep 2026 · bioRxiv · 0 citations · 48 references

Biology

TL;DR

It is demonstrated that the intestinal epithelium plays a dominant role in fecal microbiome alterations in CF and that the resultant dysbiosis contributes to CF pathogenesis.

DOI Semantic Scholar

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