Comprehensive In Silico Analysis Identifies MSTO1 and LIG1 as Candidate Biomarkers With Diagnostic and Prognostic Relevance in Hepatocellular Carcinoma
Sep 2026· Cancer Reports· Vol 9· 0 citations· 34 references
Medicine
TL;DR
This work has shown that novel molecular markers with improved sensitivity, specificity, and therapeutic relevance are essential for enhancing early detection and guiding personalized treatment strategies in HCC.
Abstract
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and remains a major cause of cancer‐related mortality worldwide. Its poor clinical outcomes are largely attributed to late‐stage diagnosis and the limited accuracy of currently available diagnostic and prognostic biomarkers. Therefore, identifying novel molecular markers with improved sensitivity, specificity, and therapeutic relevance is essential for enhancing early detection and guiding personalized treatment strategies.
Breast cancer (BC) is a disease with a subtle onset, often diagnosed late, and has a high mortality rate. This study aimed to identify long non‐coding RNAs (lncRNAs) linked to BC as prognostic markers using bioinformatics and initial experiments, explore their regulatory pathways, and assess their expression and progno...
Yu-Han Zheng, Xing-Gui Chen, Xuan Liu et al.· Cancer Medicine· 0 citations
Metabolomics is unlikely to replace existing diagnostic modalities in the near future but may substantially improve diagnostic accuracy when integrated with established biomarkers, imaging techniques, and molecular diagnostics.
Mohammad Javad Roustaye Gourabi, M. Ghafari, Anita Nikoo et al.· Health Science Reports· 0 citations
Current FDA-approved treatments for CCA include therapies targeting HER2, IDH1, FGFR2, and other key biomarkers, including therapies targeting HER2, IDH1, FGFR2, and other key biomarkers.
Augusto Almeida, Joao Manzi, Camila Hoff et al.· Translational Oncology· 1 citation
Simple Summary Pancreatic cancer remains one of the deadliest malignancies, and effective biomarkers for its detection and prognosis are still lacking. In this study, SAMD9 was consistently overexpressed in pancreatic cancer tissues and was associated with poor patient outcomes. Analyses of public datasets showed that...
Xing-Yue He, Ying Zheng, Xun-Jie Cao et al.· Cancers· 0 citations
Highlights ● Multi-omics analysis identifies a robust three-gene prognostic signature for LUAD.● The signature stratifies patients by survival and tumor immune characteristics.● High-risk tumors display proliferative programs and immunotherapy-related features.● The model predicts differential responsiveness to immune...
Huangkai Zhu, Yannan Fang, Minglei Yang et al.· Translational Oncology· 0 citations
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