Genetic and epigenetic landscape of non-familial sudden cardiac death

Interaction Between Genotype, Phenotype, and Prognosis in Patients With Dilated Cardiomyopathy.

Genetic background was associated with distinct myocardial fibrosis phenotypes and provided prognostic information beyond conventional CMR-derived fibrosis and functional phenotypes in DCM.

Epigenetic signatures of biological vulnerability and residual risk in heart failure

Higher epigenetic age and DNAm scores for CRP, frailty, and mortality were associated with increased risk, whereas higher diet-related DNAm scores were inversely associated, particularly for all-cause death.

Non-Coding RNA Biomarkers in Hypertrophic Cardiomyopathy: Diagnostic, Prognostic, Genotype-Specific and Forensic Perspectives

Background: Hypertrophic cardiomyopathy (HCM) is the most common monogenic cardiac disorder (prevalence 1:500), a major substrate of sudden cardiac death (SCD) in adolescents and young adults, and is modulated by regulatory mechanisms including non-coding RNAs (ncRNAs) such as microRNAs (miRNAs), long non-coding RNAS (...

MicroRNAs in dilated cardiomyopathy: from biomarkers to therapeutic targets

Dyslipidaemia: Pathophysiology, Epidemiology, Diagnostic Advances, and Emerging Therapeutic Strategies

This review elucidates the complex pathophysiology, epidemiological dynamics, and genetic architectures defining dyslipidaemia, delineating primary hereditary molecular defects from secondary acquired etiologies and discusses persistent barriers to patient adherence and the transformative potential of precision medicin...

Multi-omic analysis identifies mitochondrial dysfunction as a key feature of hypertrophic cardiomyopathy

Hypertrophic cardiomyopathy (HCM) is an inherited cardiovascular disorder marked by left ventricular hypertrophy, known to be caused by genetic mutations in sarcomere proteins, such as MYH7 and MYBPC3. Despite advancements in our understanding of HCM genetics, the relationship between genetic variants and clinical outc...