This review elucidates the complex pathophysiology, epidemiological dynamics, and genetic architectures defining dyslipidaemia, delineating primary hereditary molecular defects from secondary acquired etiologies and discusses persistent barriers to patient adherence and the transformative potential of precision medicine.
The rapid expansion of pharmacological therapies for obesity, type 2 diabetes, and chronic kidney disease (CKD) has transformed clinical practice and broadened the therapeutic landscape for the management of metabolic diseases. These agents provide well-established cardiometabolic and renal benefits; however, their use...
N. Borges, L. F. M. de França Cardozo, Viviane de Oliveira Leal et al.· Clinical Nutrition· 0 citations
Background: Obesity and unhealthy dietary habits are among the leading modifiable determinants of cardiovascular disease, acting through biological mechanisms that extend far beyond excess body weight. Adipose tissue dysfunction, chronic low-grade inflammation, oxidative stress, endothelial impairment, mitochondrial dy...
Francesca Marino, M. Savo, D. Cozac et al.· Journal of Clinical Medicine· 0 citations
This work proposes an executable framework for individualized atherosclerosis therapy that organizes clinical decision‐making around three axes: actionable endotype identification, selection of a matched therapeutic modality, and evaluation of delivery feasibility.
Yun-Dong Peng, Rui Li, Huan Li et al.· Medicine Bulletin· 0 citations
Type 2 diabetes mellitus (T2DM) is a complex and progressive metabolic disorder driven by interactions among genetic susceptibility, environmental influences, and metabolic dysfunction. Although insulin resistance and pancreatic β-cell dysfunction remain central to disease pathogenesis, emerging evidence highlights the...
Himanshu, Suryakant Verma, Sonam Yadav et al.· Discover Endocrinology and M...· 0 citations
ABSTRACT Cardiovascular diseases (CVDs) remain the leading cause of global mortality, and the burden is rising fastest in low‐ and middle‐income countries (LMICs). Conventional risk calculators, such as Framingham and Systematic Coronary Risk Evaluation (SCORE), incorporate age, blood pressure, cholesterol, diabetes an...
Sana Rasheed, Azka Mujeeb, M. Sarfraz et al.· Public Health Challenges· 0 citations
INTRODUCTION/OBJECTIVE
Atherosclerosis is traditionally defined as a lipid-driven inflammatory disease of medium and large arteries, but vascular inflammation also interacts with immune, autonomic, metabolic, and brain vascular pathways. This narrative review synthesizes evidence supporting an artery-immune-brain frame...
F. Epelde· Current Neuropharmacology· 0 citations
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