A case of a 55-year-old Malay woman with underlying diabetes mellitus and hypertension who presented with a one-week history of fever, confusion, back pain, and dyspnoea is described, with significant resolution of the visceral abscesses and pulmonary lesions.
Abstract
Melioidosis is a potentially fatal endemic infection caused by the Gram-negative bacterium Burkholderia pseudomallei. The disease may present with a wide spectrum of clinical manifestations, including pneumonia, visceral abscesses, and septicemia. Neurological complications are uncommon but have been reported, with dural venous sinus thrombosis being a particularly rare manifestation. We describe a case of a 55-year-old Malay woman with underlying diabetes mellitus and hypertension who presented with a one-week history of fever, confusion, back pain, and dyspnoea. Blood cultures grew Burkholderia pseudomallei, and imaging demonstrated disseminated infection with multiple splenic abscesses and pulmonary septic emboli, as well as dural venous sinus thrombosis. The patient was initially treated with intravenous meropenem, followed by ceftazidime and oral trimethoprim-sulfamethoxazole as part of eradication therapy. Therapeutic anticoagulation with enoxaparin was also initiated. Follow-up imaging demonstrated significant resolution of the visceral abscesses and pulmonary lesions.
Melioidosis, caused by Burkholderia pseudomallei, produces a wide range of clinical manifestations and may be difficult to diagnose in the pediatric population. We describe the case of a 12-year-old girl with poorly controlled type 1 diabetes mellitus that posed diagnostic challenges. Over 4 months, she experienced rel...
Nikhil John, Pediredla Karunakar, Rajashree Choudhury et al.· Paediatrics and Internationa...· 0 citations
Melioidosis caused by
Burkholderia pseudomallei
is an emerging tropical infection that frequently mimics tuberculosis in endemic regions, resulting in diagnostic delay and inappropriate therapy. We report a 50-year-old man with poorly controlled type 2 diabetes mellitus who presented with fever, abdominal distensio...
Bala Pranesh Babu, S. Mishra, Saswat Subhankar et al.· Journal of Integrative Medic...· 0 citations
The presence of severe melioidosis in the Peruvian Amazon highlights the presence of Burkholderia pseudomallei and underscores the need to consider this pathogen in patients presenting with severe sepsis in tropical regions with high environmental exposure and metabolic risk factors.
Mario Agramonte-Vilca, Stefany Alvis-Sanchez, Débora Rocío Mananita-Terrones et al.· American Journal of Tropical...· 0 citations
The case of a 48-year-old patient recently diagnosed with HIV and a CD4 lymphocyte count of less than 50 cells/ uL, who consulted for prolonged fever without apparent focus, highlights the importance of considering nocardiosis in the differential diagnosis of prolonged fever with multiple deep lesions in immunocompromi...
María Trinidad Pennini Guelfi, Camilo Martínez, Ana De Lajonquiere et al.· Medicina· 0 citations
Melioidosis, caused by Burkholderia pseudomallei, is endemic in parts of South India and can be difficult to diagnosedue to its varied clinical presentations. Lack of awareness and persistent fever despite treatment may further delaydiagnosis. We report the case of a 47-year-old man with diabetes mellitus and a history...
Darshan H, S. Narayan, Prashanth M. R.· Indian Journal of Case Repor...· 0 citations
A case of a juvenile lupus who developed disseminated Nocardia pseudobrasilienisis infection in form of necrotizing pneumonia, subcutaneous nodules and central nervous system (CNS) lesion in the right parietal lobe is reported.
