TL;DR
The study reveals that C. joufra is capable of causing mild toxicity in its long-term use which could be attributed to the bioactive compounds present in it.
Although IMI presents selectivity for insects, this study demonstrated systemic alterations and genotoxicity in rats, suggesting possible toxicity in mammals, and Histopathological analysis revealed alterations in the liver, kidneys and spleen.
Cucumis metuliferus is a commonly used medicinal herb in traditional medicine. Recent investigations showed that the peel of Cucumis metuliferus fruit contains numerous bioactive components and remains largely unexplored in terms of its bioactive potential and safety profile. Through phytochemical screening and acute,...
Paraquat is a widely used herbicide causing oxidative stress and toxicity after exposure. Despite evidence of toxicity, histological evaluation of dose-dependent hepatic and renal damage following subchronic exposure is lacking. This study aimed to investigate the effects of paraquat administration on hepatotoxicity an...
Concerns about potential harmful effects on non-target organisms are raised by the widespread use of Cypermethrin, a synthetic pyrethroid insecticide. This work used cytogenetic indicators, namely the mitotic index (MI) and micronucleus (MN) assays, to assess the cytotoxic and genotoxic effects of cypermethrin in mice....
This study provides the first demonstration that asiatic acid exerts robust systemic antioxidative, hepatoprotective, and neuroprotective effects against CPF-induced toxicity, highlighting AA’s therapeutic potential for mitigating organophosphate pesticide poisoning.
Background: Biophytum umbraculum (Welw. syn. Petersianum) is a plant endemic to Papua, Indonesia, containing several bioactive compounds, such as flavonoids, alkaloids, and saponins, which are known for their pharmacological potential. Although this plant has long been used in traditional medicine, scientific data reg...
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