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Open access Oct 2026

Hepatoprotective Effects of Dulaglutide against Methotrexate-Induced Liver Injury in Rats

Background and Objectives: The cellular antioxidant defense system is disrupted, which results in hepatotoxicity. When the antioxidant defence system is weakened, hepatocyte oxidative damage results from an increase in reactive oxygen radicals. The chemotherapeutic and immunosuppressive drug methotrexate (MTX) is often...

Omar W. Maher · 0 citations
Aug 2026

Pharmacological activities of propolis and metformin against acrylamide-induced toxicity

The improvement of biochemical and hematological markers indicated the protective role of propolis and metformin against acrylamide-induced toxicity and further studies are required to elucidate the mechanisms involved and confirm the present findings in wider experimental and clinical settings.

A. Hussein, B. Elaraby, Mohamed F. Abdelhamid et al. · 0 citations
2026

Ameliorative effect of vinpocetine on brain toxicity in rats treated with acrylamide

Vinpocetine administration ameliorated hematological disturbances, oxidative damage, and histological alterations resulting from AC administration, suggesting that vinpocetine has a protective action against AC-induced neural damage.

M. El-Maksoud, E. Shaheen · 0 citations
Sep 2026

Evaluation of the protective effects of Syzygium aromaticum L. against doxorubicin-induced cardiotoxicity in rats.

OBJECTIVE Doxorubicin (DOX), a widely used anthracycline chemotherapy drug, has the potential to cause toxicity in multiple organs, particularly the myocardium. This study examines the cardioprotective effects of Syzygium aromaticum L. extract (SAE) in DOX-induced cardiotoxicity. METHODS This study involved 48 male W...

Zahra Shahinfar, H. Poorzand, V. Askari et al. · 0 citations
Open access 2021

A long term study to unravel the chemopreventive efficacy of pMethoxycinnamic acid in comparison to sorafenib, a standard drug against NDEA induced hepatocarcinogenesis

p- Methoxycinnamic acid (p-MCA), an active phenolic compound derived from the rice bran, turmeric and Kaempferia galangal, is known to exhibit numerous pharmacological properties. We investigated that chemopreventive effect of p-MCA against N-nitrosodiethylamine (NDEA) induced hepatocarcinogenesis in male wistar rats....

Sriragavi Ravi, Rajagopal Ayyanar, N. Namasivayam · 2 citations
Open access Sep 2026

Protective Effects of 2-Chloro-3-Hydrazinylquinoxaline against Doxorubicin-induced Nephrotoxicity via Modulation of Oxidative Stress and Inflammation in Rats

Background: Doxorubicin (DOX) is a widely used anthracycline antibiotic effective against multiple human malignancies, but its clinical utility is limited by well-established nephrotoxicity that frequently manifests as acute kidney injury (AKI). In contrast, the potential nephroprotective effects of 2-chloro-3-hydrazin...

Noha A. Juma, Wafaa A. Alhazmi, N. Daffa et al. · 0 citations

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