Natural products mediate ferroptosis and immune microenvironment-linked sensitization in osteosarcoma: from chemotherapy resistance to combined therapeutic transformation.

NRF2-Regulated Ferroptosis in Breast Cancer: Mechanisms, Resistance, and Therapeutic Opportunities.

The molecular mechanisms by which NRF2 regulates ferroptosis, including KEAP1-NRF2 signaling, metabolic rewiring, iron homeostasis, lipid remodeling, and crosstalk with p53 and other stress-response pathways are summarized.

The Emerging Role of Ferroptosis in Pediatric Cancer Biology and Therapy

This review summarizes the molecular mechanisms underlining the relationship between ferroptosis and cancer biology, tumor progression, tumor microenvironment, and therapy resistance, with particular interest in its emerging relevance and therapeutic potential in pediatric oncology, while critically considering the cur...

Phytochemical-drug combinations in osteosarcoma: Mechanistic vulnerabilities, evidence quality and translational challenges.

Osteosarcoma remains a major therapeutic challenge because of metastatic progression, recurrence and intrinsic or acquired resistance to conventional chemotherapy. Phytochemicals have emerged as potential complementary agents because of their ability to modulate multiple biological processes associated with osteosarcom...

Revisiting Cell Death in Colorectal Cancer: The Rise of Ferroptosis as a Therapeutic Opportunity.

Colorectal cancer (CRC) remains a global health concern and a leading cause of cancer mortality, where therapeutic resistance persists as the central barrier to sustained response. Most conventional therapies rely on apoptosis, but CRC frequently resists through p53 alterations, anti-apoptotic BCL-2 upregulation, and d...

Ferroptosis and tumor microenvironment: orchestrating therapy resistance, immune evasion, and metastatic events

Pharmacological targeting of ferroptosis in cancer: mechanisms, tumor immunity, and translational challenges.

Ferroptosis is an iron-dependent form of regulated cell death driven by phospholipid peroxidation and the failure of cellular antioxidant defenses. Its close integration with iron metabolism, lipid remodeling, and redox homeostasis has identified ferroptosis as a potentially exploitable vulnerability in cancer. This re...