Aug 2026· Polymers for Advanced Technologies· Vol 37· 0 citations· 103 references
TL;DR
The interactive combination of physics‐based structural engineering and chemistry‐based functional modification offers an efficient framework for developing the next‐generation nanofiber‐based drug delivery systems.
Abstract
Nanofiber technology is a revolutionary platform for drug delivery due to its unique physicochemical characteristics, including a high surface‐to‐volume ratio, adjustable porosity, modifiable mechanical strength, and customizable surface chemistry. Combining nanoscale physics and polymer chemistry allows the directed loading, release rates and interaction with biology to be controlled. This review critically examines the underlying physics and chemistry of nanofiber manufacturing and their effects on drug delivery, transport, biological behavior, and clinical translation potential. A literature‐based study was undertaken that was based upon the principles of electrospinning, the chemistry of polymers, incorporation of drugs, kinetics of drug transport, mathematical models, physicochemical characterization, biological interactions and emerging multifunctional nanofiber systems. Diffusion and polymer degradation are the most important mechanisms that determine the release of drugs through nanofibers and are highly dependent on the morphology, porosity, hydrophilicity, and molecular interactions of the nanofibers. The recent developments in stimuli‐responsive and hybrid nanofiber systems also allow the targeted, personalized, and controlled delivery of therapeutics. The interactive combination of physics‐based structural engineering and chemistry‐based functional modification offers an efficient framework for developing the next‐generation nanofiber‐based drug delivery systems. Nevertheless, even with the issues of scalability and regulation, innovations are increasing at a rate that makes them clinically applicable.
Overall, this review shows that nanofiber-based drug delivery systems have significant advantages over conventional dosage forms and demonstrate considerable potential for next-generation therapies and pharmaceutical products with systematic formulation optimization, standardized characterization protocols, and clinically relevant evaluation strategies.
P. S. Patil, P. Pawar· Current Nanomaterials· 0 citations
The development of sustainable and functional surface coatings has become a central theme in materials science due to increasing environmental concerns and expanding biomedical needs. This study reports the preparation and characterization of bio-based polylactic acid (PLA) nanofibrous coatings fabricated by electrospinning, aimed at delivering biodegradable and bioactive surfaces with controlled release functionality. Electrospinning enabled the formation of uniform nanofibrous coatings with high surface area and morphology reminiscent of extracellular matrices, presenting potential as multifunctional coating platforms. The obtained coatings were systematically evaluated for their physicochemical and biological properties, including antioxidant activity, cytocompatibility, and the controlled release of acetylsalicylic acid as a model bioactive agent. Release behavior was analyzed to elucidate the dominant transport mechanisms, revealing a biphasic profile characterized by an initial burst followed by sustained diffusion-controlled release. These results demonstrate that the electrospun PLA coatings successfully combine biodegradability, bioactivity, and tunable release properties within a bio-based polymer coating format. The findings highlight the potential of such bio-based polymer coatings for biomedical applications where biodegradable and functional surface solutions are required, and contribute to the broader advancement of eco-friendly and multifunctional coating technologies.
J. Radwan-Pragłowska, M. Nicieja, Ł. Janus et al.· Coatings· 0 citations
Controlled and sustained drug delivery has emerged as a transformative strategy for overcoming the limitations of conventional pharmaceutical formulations, including poor bioavailability, rapid drug clearance, systemic toxicity, and non-specific distribution. Among the numerous delivery platforms investigated, polymeric nanocomposite carriers have attracted considerable attention because they integrate the excellent biocompatibility, biodegradability, and processability of polymers with the unique physicochemical, mechanical, optical, magnetic, and therapeutic properties of inorganic nanomaterials. This review provides a comprehensive and critical evaluation of recent advances in polymeric nanocomposite-based drug delivery systems, highlighting the synergistic interactions between natural and synthetic polymers and a broad spectrum of nanofillers, including metal and metal oxide nanoparticles, carbon-based nanomaterials, nanoclays, mesoporous materials, and electrospun nanofibers. The influence of nanocomposite composition, fabrication strategies, and physicochemical characteristics on drug loading, encapsulation efficiency, release kinetics, targeting capability, and biological performance is systematically discussed. Furthermore, representative therapeutic applications in cancer therapy, wound healing, antimicrobial treatment, tissue engineering, neurological disorders, and regenerative medicine are critically compared to establish structure–property–performance relationships. This review primarily summarizes individual carrier systems, preparation methods, release mechanisms, and biomedical applications into a unified framework while identifying current limitations related to nanoparticle aggregation, long-term biocompatibility, biodegradation, large-scale manufacturing, regulatory approval, and clinical translation. This review provides valuable insights for researchers working on the rational design of advanced polymeric nanocomposites with enhanced therapeutic efficacy, improved safety, and accelerated clinical applicability.
M. Samy· Kompleksnoe Ispolzovanie Min...· 0 citations
This review critically evaluates the design parameters of biopolymer delivery systems, focusing on the optimization of particle size and drug loading capacity and addresses key translational hurdles, including the biological limitations of active targeting and safety concerns like complement activation-related pseudoallergy.
The development of efficient and targeted drug delivery systems remains a significant challenge, particularly for active pharmaceutical ingredients with poor aqueous solubility. Among various nanocarrier systems, Mesoporous Silica Nanoparticles (MSNs) have emerged as promising candidates due to their high surface area, tunable pore size (2-50 nm), thermal stability, and chemical modifiability. This review comprehensively discusses the rationale behind the utilization of MSN as drug delivery systems, focusing on how the type and concentration of surfactants, along with surface functionalization strategies, influence their physicochemical characteristics and pharmacokinetic performance. The synthesis of MSNs typically involves sol-gel processes using silica precursors (e.g., tetraethyl orthosilicate) and surfactants (e.g., cetyl trimethyl ammonium bromide, Pluronic F127), which dictate the morphology, particle size, and pore architecture of the resulting nanoparticles. Furthermore, surface modifications employing functional groups such as polyethylene glycol or pH-responsive polymers enhance biocompatibility, prolong systemic circulation, and enable controlled and site-specific drug release. Evidence from recent studies demonstrates that MSNs significantly improve drug loading efficiency, enhance solubility and bioavailability, and reduce off-target toxicity. Consequently, MSNs represent a highly versatile and modifiable platform with considerable potential for addressing the limitations of conventional drug delivery systems, particularly in oncology and the treatment of chronic diseases.
Ahmad Ainurofiq, Y. Ramadhana, Salma Aqilah Rachmadani et al.· Recent Advances in Drug Deli...· 0 citations
