Overall, this review shows that nanofiber-based drug delivery systems have significant advantages over conventional dosage forms and demonstrate considerable potential for next-generation therapies and pharmaceutical products with systematic formulation optimization, standardized characterization protocols, and clinically relevant evaluation strategies.
Abstract
Considering that nanofibers can precisely control drug loading, release kinetics, and therapeutic performance, they have become a highly attractive platform for improved drug delivery systems. Because it enables the production of continuous nanofibers with customizable designs, such as
core–shell, porous, aligned, and multi-component structures, electrospinning is the most commonly
used approach among the many fabrication methods. These structural characteristics allow for the
effective encapsulation of a wide range of medications and provide significant advantages in terms of
formulation versatility. High drug encapsulation efficiency, improved solubility and bioavailability
of poorly water-soluble drugs, and adaptable release patterns that can be customized for immediate,
sustained, or targeted delivery have all been repeatedly reported with electrospun nanofibers. Crucially, drug–polymer interactions, the physical stability of the loaded drug, and the predominant release mechanisms—such as diffusion, polymer degradation, or swelling-controlled transport—are all
directly impacted by nanoscale structural control. Furthermore, enhanced mass transfer and enhanced
contact with biological environments are made possible by nanofibers' high surface area-to-volume
ratio. Nanofibrous scaffolds are particularly appealing for tissue engineering and wound healing
applications because of their extracellular matrix-mimicking morphology, which improves cell adhesion, proliferation, and tissue integration in addition to medication administration. Overall, this review shows that nanofiber-based drug delivery systems have significant advantages over conventional dosage forms. They also demonstrate considerable potential for next-generation therapies and
pharmaceutical products with systematic formulation optimization, standardized characterization
protocols, and clinically relevant evaluation strategies. Furthermore, the incorporation of intelligent
and stimuli-responsive nanofibers could increase their usefulness for precision and personalized
therapy
The interactive combination of physics‐based structural engineering and chemistry‐based functional modification offers an efficient framework for developing the next‐generation nanofiber‐based drug delivery systems.
Madhavi Porwal, Phool Chandra, S. Sridhar et al.· Polymers for Advanced Techno...· 0 citations
Controlled and sustained drug delivery has emerged as a transformative strategy for overcoming the limitations of conventional pharmaceutical formulations, including poor bioavailability, rapid drug clearance, systemic toxicity, and non-specific distribution. Among the numerous delivery platforms investigated, polymeric nanocomposite carriers have attracted considerable attention because they integrate the excellent biocompatibility, biodegradability, and processability of polymers with the unique physicochemical, mechanical, optical, magnetic, and therapeutic properties of inorganic nanomaterials. This review provides a comprehensive and critical evaluation of recent advances in polymeric nanocomposite-based drug delivery systems, highlighting the synergistic interactions between natural and synthetic polymers and a broad spectrum of nanofillers, including metal and metal oxide nanoparticles, carbon-based nanomaterials, nanoclays, mesoporous materials, and electrospun nanofibers. The influence of nanocomposite composition, fabrication strategies, and physicochemical characteristics on drug loading, encapsulation efficiency, release kinetics, targeting capability, and biological performance is systematically discussed. Furthermore, representative therapeutic applications in cancer therapy, wound healing, antimicrobial treatment, tissue engineering, neurological disorders, and regenerative medicine are critically compared to establish structure–property–performance relationships. This review primarily summarizes individual carrier systems, preparation methods, release mechanisms, and biomedical applications into a unified framework while identifying current limitations related to nanoparticle aggregation, long-term biocompatibility, biodegradation, large-scale manufacturing, regulatory approval, and clinical translation. This review provides valuable insights for researchers working on the rational design of advanced polymeric nanocomposites with enhanced therapeutic efficacy, improved safety, and accelerated clinical applicability.
M. Samy· Kompleksnoe Ispolzovanie Min...· 0 citations
The development of nanoparticle-based drug delivery systems represents a major step forward in pharmaceutical science, with the goal of enhancing treatment effectiveness while ensuring patient safety. Among these systems, polymeric nanoparticles-especially those made from biodegradable materials-have gained considerable interest due to their biocompatibility and versatile structural properties. Through careful formulation approaches, including surface modification, appropriate polymer selection, and optimization of physicochemical properties, these carriers can achieve sustained and controlled drug release. Such controlled release helps maintain stable drug levels in the bloodstream, reduces dosing frequency, and minimizes adverse effects. Furthermore, incorporating targeting strategies allows for more precise drug delivery by promoting accumulation at specific sites of action. In addition, advanced stimuli-responsive systems introduce an extra level of regulation, enabling drug release in response to specific biological triggers like pH changes, temperature variations, or enzymatic activity. This review highlights key design principles, explores mechanisms underlying controlled and targeted delivery, and discusses the growing importance of smart polymeric systems in the evolving field of nanomedicine.
Babitha Ms, Kamaleshwari Ms, P. Preetha et al.· International journal for de...· 0 citations
Findings establish chitosan-coated, cholesterol-Tween niosomes as versatile, biocompatible carriers that provide sustained release and preserve bioactivity, with promising potential for ocular drug delivery and broader biomedical applications.
Sony Moni Das, Z. Fatima, P. Awat et al.· Physical Chemistry, Chemical...· 0 citations
The development of efficient and targeted drug delivery systems remains a significant challenge, particularly for active pharmaceutical ingredients with poor aqueous solubility. Among various nanocarrier systems, Mesoporous Silica Nanoparticles (MSNs) have emerged as promising candidates due to their high surface area, tunable pore size (2-50 nm), thermal stability, and chemical modifiability. This review comprehensively discusses the rationale behind the utilization of MSN as drug delivery systems, focusing on how the type and concentration of surfactants, along with surface functionalization strategies, influence their physicochemical characteristics and pharmacokinetic performance. The synthesis of MSNs typically involves sol-gel processes using silica precursors (e.g., tetraethyl orthosilicate) and surfactants (e.g., cetyl trimethyl ammonium bromide, Pluronic F127), which dictate the morphology, particle size, and pore architecture of the resulting nanoparticles. Furthermore, surface modifications employing functional groups such as polyethylene glycol or pH-responsive polymers enhance biocompatibility, prolong systemic circulation, and enable controlled and site-specific drug release. Evidence from recent studies demonstrates that MSNs significantly improve drug loading efficiency, enhance solubility and bioavailability, and reduce off-target toxicity. Consequently, MSNs represent a highly versatile and modifiable platform with considerable potential for addressing the limitations of conventional drug delivery systems, particularly in oncology and the treatment of chronic diseases.
Ahmad Ainurofiq, Y. Ramadhana, Salma Aqilah Rachmadani et al.· Recent Advances in Drug Deli...· 0 citations
This review provides a comprehensive assessment of four major nanoparticle families—polymeric carriers, lipid-based vehicles, inorganic systems, inorganic systems, and hybrid composites—focusing on how their physicochemical properties govern drug encapsulation, release behavior, and tissue compatibility.
Z. Asiri, Abeer Mobarki, Sahar S. Alghamdi et al.· International Journal of Mol...· 0 citations