Evaluating and Comparing Immunization Level of the Recombinant Proteins, Binding Domain of Tetanus Neurotoxin and B Subnnit of Heat Labile Toxin of Escherichia coli, and their Relation to Immunological Memory
The first step in creating a strong and long-lasting immune-ological memory is the induction of high titer of antibody, and the difference in antibody titer may be related to memory cells lifetime in the immunized mice.
Findings support the feasibility of the multi-epitope construct and provide a foundation for future investigations of its immunogenicity and protective efficacy studies in animal models.
Nadálin Yandra Botton, Guilherme Feijó de Sousa, Marina Sturbelle Garcia et al.· Journal of Biotechnology· 0 citations
This study evaluated the suitability and immunobiological characteristics of the attenuated strain CP-65 K for the development of a cowpox vaccine. The attenuated strain CP-65 K was non-reactogenic in both laboratory and target animals and demonstrated higher immunogenicity than vaccinia virus (VACV) strains RIBSP-B an...
D. Muzarap, Anar Dzhaldybayeva, M. Mambetaliyev et al.· Vaccine· 0 citations
Background and Objectives: West Nile virus (WNV) is a mosquito-borne flavivirus that represents a significant public health concern, and the development of effective vaccine candidates remains a priority. This study aimed to design a chimeric multi-epitope protein against WNV using immunoinformatics approaches and eval...
M. Arezoumandi, Sadegh Shojaei Baghini, Nima Rad et al.· Iranian Journal of Microbiol...· 0 citations
Giardiasis is caused by the widespread intestinal parasite Giardia lamblia. The characterization of immunogenic proteins in G. lamblia has been investigated to identify potential vaccine targets, including members of the giardin family, variant-specific surface proteins (VSPs), cyst wall proteins (CWPs) and heat shock...
Thania Garzon, K. Esparza, David Ortega et al.· Parasitology international· 0 citations
The generation of chicken-derived scFv antibodies targeting the FCV VP1-CDEF' region are reported, with high-affinity clones 2B2 and 2E1 are promising candidates for rapid diagnostic test development and warrant further evaluation.
Yan-Quan Wei, Yi-Han Liu, Zhen Han et al.· Frontiers in Microbiology· 0 citations
Mycobacterium avium subsp. paratuberculosis (MAP) causes Johne’s disease in ruminants and is difficult to control once persistent infection is established. We designed a MAP multi-epitope vaccine candidate by screening conserved proteins and assembling predicted B-cell, MHC class I-restricted cytotoxic T lymphocyte (CT...
