Thermosensitive Hydrogels Based on Combination of Pluronics As New Delivery Systems for Leflunomide

Influence of Formulation Composition and Rheological Properties on the Stability of PnPP19 Peptide in Thermoresponsive Hydrogels

Peptide-based drugs present high specificity and therapeutic potential but remain limited by poor physicochemical stability, particularly in aqueous and semi-solid systems. Thermoresponsive poloxamer hydrogels have emerged as promising platforms for the formulation of peptide-based therapeutics. This study investigates...

Rheological Modeling to Assess the Gelation Kinetics of Mono- and Multicomponent Supramolecular Hydrogels.

Supramolecular hydrogels based on peptides have emerged as versatile soft materials owing to their biocompatibility, modularity, and tunable mechanical properties. To overcome the limitations of natural peptide sequences, nucleobase-peptide hybrids (nucleopeptides) have been developed, enabling coassembly and enhanced...

Form-Stable Hydrogel Carriers Based on Chitosan and Sodium Alginate for Sustained Drug Release

Hydrogels with an equimolar ratio of the polyelectrolytes in the mixture were found to have the highest consistency coefficient and, accordingly, the lowest flow behavior index, as well as the highest uniaxial compressive strength.

Unlocking the Potential of Poloxamine 908 for Injectable Nanocomposite Hydrogels: Rheological Performance, Dissolution Behavior and Sustained Drug Release

Background/Objectives: Poloxamine 908 (P908), an amphiphilic block copolymer with thermo- and pH-responsive properties, was demonstrated to be a biomaterial that can be employed for the development of injectable hydrogels. The present study aimed to investigate the influence of nanoparticles with different chemical com...

Advanced crosslinking strategies in Pluronic F127-based hydrogels

EFFECT OF POLYMER COMPOSITION AND TEMPERATURE ON THE RHEOLOGICAL PROPERTIES OF CHITOSAN-CARBOXYMETHYL CELLULOSE HYDROGELS

Over the past decade, superabsorbent hydrogels based on natural polymers (cellulose, chitosan) have been widely applied in biomedicine. Despite their high stability and biocompatibility, these hydrogels exhibit several drawbacks associated with insufficient pseudoplasticity and thixotropy. Consequently, the development...